ArticleCureus2026
Unmasked Behavioral Disturbance Following Traumatic Brain Injury in an Adult With Previously Undiagnosed Sotos Syndrome.
Article in Cureus, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Abstract
Sotos syndrome is a rare autosomal dominant disorder characterized by childhood overgrowth, including tall stature and macrocephaly, distinctive facial appearance, and neuropsychiatric manifestations. These features include intellectual disability and a broad spectrum of behavioral disturbances. Traumatic brain injury (TBI) is also known to cause various neuropsychiatric symptoms, including behavioral disturbances, even in individuals without underlying medical conditions. However, the influence of pre-existing neurodevelopmental disorders such as Sotos syndrome on behavioral outcomes following TBI remains incompletely understood. We report the case of a 35-year-old man with previously undiagnosed Sotos syndrome who developed severe behavioral disturbances following TBI. Based on his history of childhood overgrowth and characteristic dysmorphic facial features, Sotos syndrome was suspected and subsequently confirmed by genetic testing, which demonstrated a heterozygous whole-gene deletion of the causative gene,
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