Evidence map›Paper›PMID 42621478›Full record

ArticleACS medicinal chemistry letters2026

Identification and Studies of Highly Potent and Selective Heterobifunctional Galectin‑3 Degraders.

Chunjian Liu, Wei Wang, Aaron J Balog, Sarah Traeger, Manoranjan Panda, Narasimharaju Kalidindi, Ari Salinger, Yuka Amako, Ashok R Dongre, Gregory Locke and 8 more

Abstract read
In one paragraph

Article in ACS medicinal chemistry letters, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Chunjian LiuResearch & Early Development, Bristol Myers Squibb Company, Princeton, New Jersey 08543, United States.ORCID https://orcid.org/0000-0003-3708-2372
Wei WangResearch & Early Development, Bristol Myers Squibb Company, Princeton, New Jersey 08543, United States.
Aaron J BalogResearch & Early Development, Bristol Myers Squibb Company, Princeton, New Jersey 08543, United States.
Sarah TraegerResearch & Early Development, Bristol Myers Squibb Company, Princeton, New Jersey 08543, United States.
Manoranjan PandaResearch & Early Development, Bristol Myers Squibb Company, Princeton, New Jersey 08543, United States.
Narasimharaju KalidindiBiocon-Bristol Myers Squibb Research and Development Center, Bangalore 560099, India.
Ari SalingerResearch & Early Development, Bristol Myers Squibb Company, Cambridge, Massachusetts 02141, United States.
Yuka AmakoResearch & Early Development, Bristol Myers Squibb Company, Cambridge, Massachusetts 02141, United States.
Ashok R DongreResearch & Early Development, Bristol Myers Squibb Company, Cambridge, Massachusetts 02141, United States.
Gregory LockeResearch & Early Development, Bristol Myers Squibb Company, Princeton, New Jersey 08543, United States.
Fei YuResearch & Early Development, Bristol Myers Squibb Company, Princeton, New Jersey 08543, United States.
John A NewittResearch & Early Development, Bristol Myers Squibb Company, Princeton, New Jersey 08543, United States.
Susan E KieferResearch & Early Development, Bristol Myers Squibb Company, Princeton, New Jersey 08543, United States.
Joseph NaglichResearch & Early Development, Bristol Myers Squibb Company, Princeton, New Jersey 08543, United States.
Dong ChengResearch & Early Development, Bristol Myers Squibb Company, Princeton, New Jersey 08543, United States.
Harinath SaleBiocon-Bristol Myers Squibb Research and Development Center, Bangalore 560099, India.
Bruce A EllsworthResearch & Early Development, Bristol Myers Squibb Company, Princeton, New Jersey 08543, United States.
Alicia Regueiro-RenResearch & Early Development, Bristol Myers Squibb Company, Princeton, New Jersey 08543, United States.ORCID https://orcid.org/0000-0003-2991-719X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

On the basis of an X-ray cocrystal structure of our previously disclosed monosaccharide-derived galectin-3 inhibitor

Indexed as

galectin-3 (gal-3)galectin-3 (gal-3) degradationgalectin-3 (gal-3) degradersglobal proteomics analysistargeted protein degradation

Identifiers

PMID42621478
PMCPMC13488380

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.