Evidence map›Paper›PMID 42621453›Full record

ArticleWorld journal of otorhinolaryngology - head and neck surgery2026

Effects of Obstructive Sleep Apnea on Personality and Temperament: A Cohort and Mendelian Randomization Study.

Jian-Hong Liao, Yun-Han Shi, Xin-Peng Xu, Yan-Ru Li, De-Min Han

Abstract read
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In one paragraph

Article in World journal of otorhinolaryngology - head and neck surgery, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Jian-Hong LiaoObstructive Sleep Apnea-Hypopnea Syndrome Clinical Diagnosis and Therapy and Research Centre, Beijing Tongren Hospital Capital Medical University Beijing China.ORCID https://orcid.org/0000-0003-2465-3850
Yun-Han ShiObstructive Sleep Apnea-Hypopnea Syndrome Clinical Diagnosis and Therapy and Research Centre, Beijing Tongren Hospital Capital Medical University Beijing China.
Xin-Peng XuBeijing Key Laboratory of Mental Disorders, National Clinical Research Center for Mental Disorders & National Center for Mental Disorders, Beijing Anding Hospital Capital Medical University Beijing China.
Yan-Ru LiObstructive Sleep Apnea-Hypopnea Syndrome Clinical Diagnosis and Therapy and Research Centre, Beijing Tongren Hospital Capital Medical University Beijing China.
De-Min HanObstructive Sleep Apnea-Hypopnea Syndrome Clinical Diagnosis and Therapy and Research Centre, Beijing Tongren Hospital Capital Medical University Beijing China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: Obstructive sleep apnea (OSA) is associated with neurocognitive impairment, but its causal relationship with personality traits remains poorly understood. This study investigates the association and causality between OSA and personality using both cohort and genetic data. Method: This study included adults undergoing full-night polysomnography (PSG). Personality traits were assessed using the Eysenck Personality Questionnaire (EPQ), which assesses extraversion, neuroticism, psychoticism, and lie scales. Based on Eysenck's theory, participants were classified into melancholic, choleric, phlegmatic, and sanguine temperaments. Bidirectional Mendelian randomization (MR) analysis was conducted using GWAS data from the FinnGen database to infer causality. The inverse-variance weighted (IVW) method was used as the primary analysis. Sensitivity, pleiotropy, and heterogeneity analyses were conducted to validate the results. Results: A total of 233 participants were included. OSA was associated with significantly reduced neuroticism ( Conclusions: OSA may contribute to reduced neuroticism and altered temperament, highlighting the need for psychological screening in OSA management. Caution is warranted in interpreting causality due to modest MR effect sizes and potential heterogeneity.

Indexed as

cohort studyMendelian randomizationobstructive sleep apneapersonality characteristicstemperament

Identifiers

PMID42621453
PMCPMC13488125

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.