ArticleACS medicinal chemistry letters2026
A Rationally Engineered Norfloxacin-Phenoxazine Hybrid as a Dual-Function Anticancer Agent: DNA Intercalation Synergizes with Topoisomerase II Inhibition against Murine Breast Tumor.
Article in ACS medicinal chemistry letters, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Breast cancer therapy is compromised by acquired resistance and systemic toxicity, necessitating new therapeutic strategies. Herein, a series of hybrid molecules were synthesized by conjugating nononcogenic FDA-approved norfloxacin with DNA-targeting phenoxazine/phenothiazine through alkyl, amide, and triazole linkers. Photophysical studies demonstrated DNA intercalation, while molecular docking revealed stable interactions with topoisomerase II. The hybrids showed selective cytotoxicity against breast cancer cells, with compound
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