Evidence map›Paper›PMID 42621432›Full record

ArticleACS medicinal chemistry letters2026

Targeting

B Owen Garrett, Parvathy Babu, Bhavitavya Nijampatnam, Abhishek Govindan, Norbert Schormann, Manisha Patel, Gregory Harber, Suzanne M Michalek, Hui Wu, Champion Deivanayagam and 1 more

Abstract read
In one paragraph

Article in ACS medicinal chemistry letters, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

B Owen Garrett†Department of Chemistry, ‡Department of Biochemistry and Molecular Genetics, §Department of Microbiology, and ∥Global Center for Craniofacial Oral and Dental Disorders, University of Alabama at Birmingham, Birmingham, Alabama 35294, United States.ORCID https://orcid.org/0000-0002-8665-1001
Parvathy Babu†Department of Chemistry, ‡Department of Biochemistry and Molecular Genetics, §Department of Microbiology, and ∥Global Center for Craniofacial Oral and Dental Disorders, University of Alabama at Birmingham, Birmingham, Alabama 35294, United States.
Bhavitavya Nijampatnam†Department of Chemistry, ‡Department of Biochemistry and Molecular Genetics, §Department of Microbiology, and ∥Global Center for Craniofacial Oral and Dental Disorders, University of Alabama at Birmingham, Birmingham, Alabama 35294, United States.
Abhishek Govindan†Department of Chemistry, ‡Department of Biochemistry and Molecular Genetics, §Department of Microbiology, and ∥Global Center for Craniofacial Oral and Dental Disorders, University of Alabama at Birmingham, Birmingham, Alabama 35294, United States.
Norbert Schormann†Department of Chemistry, ‡Department of Biochemistry and Molecular Genetics, §Department of Microbiology, and ∥Global Center for Craniofacial Oral and Dental Disorders, University of Alabama at Birmingham, Birmingham, Alabama 35294, United States.
Manisha Patel†Department of Chemistry, ‡Department of Biochemistry and Molecular Genetics, §Department of Microbiology, and ∥Global Center for Craniofacial Oral and Dental Disorders, University of Alabama at Birmingham, Birmingham, Alabama 35294, United States.
Gregory Harber†Department of Chemistry, ‡Department of Biochemistry and Molecular Genetics, §Department of Microbiology, and ∥Global Center for Craniofacial Oral and Dental Disorders, University of Alabama at Birmingham, Birmingham, Alabama 35294, United States.
Suzanne M Michalek†Department of Chemistry, ‡Department of Biochemistry and Molecular Genetics, §Department of Microbiology, and ∥Global Center for Craniofacial Oral and Dental Disorders, University of Alabama at Birmingham, Birmingham, Alabama 35294, United States.
Hui WuDepartment of Biomaterial and Biomedical Science, Oregon Health and Science University, Portland, Oregon 97239, United States.ORCID https://orcid.org/0000-0003-1694-3954
Champion Deivanayagam†Department of Chemistry, ‡Department of Biochemistry and Molecular Genetics, §Department of Microbiology, and ∥Global Center for Craniofacial Oral and Dental Disorders, University of Alabama at Birmingham, Birmingham, Alabama 35294, United States.
Sadanandan E VeluCenter for Clinical and Translational Sciences, University of Alabama at Birmingham, Birmingham, Alabama 35294, United States.ORCID https://orcid.org/0000-0002-0342-2378

Funding

Dental Academic Research Training Program (DART)T90DE022736 · NIDCR · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Amjad Javed · 2012 to 2026
$6.7M
SMALL MOLECULE INHIBITORS OF CARIOGENIC BIOFILMSR01DE022350 · NIDCR · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Christian Corey Melander, Hui Wu · 2012 to 2026
$4.3M
The Structural and Functional Determination of Streptococcus mutans AdherenceR01DE029007 · NIDCR · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI DEIVANAYAGAM, CHAMPION CHRISTDOSS SELVAKUMAR, WU, HUI · 2020 to 2024
$2.1M
Structural and Functional Studies on the Glucosyltransferases of the Dental Caries Pathogen Streptococcus mutansR01DE033232 · NIDCR · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Champion Christdoss Selvakumar Deivanayagam, Hui Wu · 2024 to 2026
$1.9M
Microbial Biofilms as Regulators of Amphetamine Use DisordersR21DA059844 · NIDA · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI CARTER, ANGELA MICHELLE, VELU, SADANANDAN E. · 2024 to 2025
$408k
Hydrogel encapsulated biofilm inhibitors for dental caries prevention and treatmentR21DE028349 · NIDCR · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI VELU, SADANANDAN E. · 2019 to 2020
$396k
NIDA NIH HHS R21 DA059844NIDCR NIH HHS R01 DE022350NIDCR NIH HHS R01 DE029007NIDCR NIH HHS R01 DE033232NIDCR NIH HHS R21 DE028349NIDCR NIH HHS T90 DE022736
6 · The paper itself

Abstract

We employed structure-based drug design to target the V-region of

Indexed as

Antigen I/IIbiofilmC. albicansdental cariesinhibitorS. mutans

Identifiers

PMID42621432
PMCPMC13488099

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.