Evidence map›Paper›PMID 42621424›Full record

ArticleACS medicinal chemistry letters2026

Peptidic Phosphonates as Irreversible Covalent Inhibitors of

Armands Kazia, Elina Lidumniece, Chrislaine Withers-Martinez, Liva Eglite, Owain Donnelly, David A Fidock, Michael J Blackman, Aigars Jirgensons

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS medicinal chemistry letters, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Armands KaziaLatvian Institute of Organic Synthesis, Aizkraukles 21, LV-1006 Riga, Latvia.
Elina LidumnieceLatvian Institute of Organic Synthesis, Aizkraukles 21, LV-1006 Riga, Latvia.
Chrislaine Withers-MartinezMalaria Biochemistry Laboratory, The Francis Crick Institute, London NW1 1AT, United Kingdom.
Liva EgliteLatvian Institute of Organic Synthesis, Aizkraukles 21, LV-1006 Riga, Latvia.
Owain DonnellyDepartment of Microbiology & Immunology, Columbia University Irving Medical Centre, New York, New York 10032, United States.
David A FidockDepartment of Microbiology & Immunology, Columbia University Irving Medical Centre, New York, New York 10032, United States.
Michael J BlackmanMalaria Biochemistry Laboratory, The Francis Crick Institute, London NW1 1AT, United Kingdom.ORCID https://orcid.org/0000-0002-7442-3810
Aigars JirgensonsLatvian Institute of Organic Synthesis, Aizkraukles 21, LV-1006 Riga, Latvia.ORCID https://orcid.org/0000-0002-8937-8792

Funding

Defining the complex genetic basis of Plasmodium falciparum resistance to artemisinin and quinine and identifying resistance-refractory therapeuticsR01AI185559 · NIAID · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI David A Fidock · 2024 to 2026
$1.9M
NIAID NIH HHS R01 AI185559
6 · The paper itself

Abstract

Malaria, caused by

Indexed as

covalent inhibitiondiaryl phosphonatesinhibitorsMalariaserine proteaseSUB1

Identifiers

PMID42621424
PMCPMC13488118

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.