ArticleMolecular therapy. Nucleic acids2026
Polyamines are i-motif disruptors.
Article in Molecular therapy. Nucleic acids, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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6 authors.
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Abstract
Polyamines are vital polycations involved in diverse cellular processes and nucleic acid interactions. However, a precise molecular mechanism for their gene regulatory roles, particularly through specific DNA secondary structures, is unclear. We report that the biogenic polyamines spermine, spermidine, and putrescine selectively destabilize DNA i-motif structures.
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