ArticleAmerican heart journal plus : cardiology research and practice2026
Recurrent unexplained resting sinus tachycardia as a marker of adverse cardiovascular outcomes in cancer patients.
Article in American heart journal plus : cardiology research and practice, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Recurrent unexplained resting sinus tachycardia is common in cancer patients and is frequently attributed to reversible physiologic stressors. Whether unexplained resting sinus tachycardia is associated with adverse cardiovascular outcomes (ACVO) and mortality in oncology populations remains poorly defined. Methods: This retrospective cohort study enrolled 198 adults with confirmed cancer and ≥ 3 electrocardiogram (ECG) studies during 3 separate hospital encounters at a tertiary center (January 2019-January 2026). Patients with ≥3 ECG-confirmed episodes of unexplained resting sinus tachycardia ( Results: Patients with recurrent resting sinus tachycardia had significantly lower hemoglobin (9.8 ± 1.4 vs. 11.1 ± 2.3 g/dL; Conclusion: Recurrent unexplained resting sinus tachycardia identifies patients with cancer at increased risk of both MACE and ACVO, although residual confounding may have inflated the observed associations. Sinus tachycardia was not independently associated with mortality after adjustment for illness burden. Recurrent sinus tachycardia may serve as an accessible marker of cardiovascular vulnerability that warrants prospective investigation in cardio-oncology.
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