Evidence map›Paper›PMID 42621395›Full record

ReviewChemical science2026

Computational alanine scanning with GBSA and interaction entropy: a review of methodologies and applications in protein-protein and protein-ligand binding.

Xiao Liu, Xiaole Xu, Li Li Duan, John Z H Zhang

Abstract readReview
In one paragraph

Review in Chemical science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Xiao LiuSchool of Mathematics, Physics and Statistics, Shanghai University of Engineering Science Shanghai 201620 China xiaoliu@sues.edu.cn.ORCID https://orcid.org/0000-0002-8587-2355
Xiaole XuSchool of Physics and Optoelectronics, Shandong Normal University Jinan 250358 China duanll@sdnu.edu.cn.
Li Li DuanSchool of Physics and Optoelectronics, Shandong Normal University Jinan 250358 China duanll@sdnu.edu.cn.ORCID https://orcid.org/0000-0003-3838-1956
John Z H ZhangFaculty of Synthetic Biology, Shenzhen University of Advanced Technology Shenzhen 518107 China jz2@nyu.edu.ORCID https://orcid.org/0000-0003-4612-1863

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Computational alanine scanning (CAS) has emerged as a powerful

Identifiers

PMID42621395
PMCPMC13487539

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.