Evidence map›Paper›PMID 42621310›Full record

ReviewPostepy dermatologii i alergologii2026

Natural rubber latex allergy: causes, symptoms, and modern diagnostic methods.

Maria Zofia Lisiecka, Joanna Luczak

Abstract readReview
In one paragraph

Review in Postepy dermatologii i alergologii, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Maria Zofia LisieckaIndividual Specialist Medical Practice, Warsaw, Poland.
Joanna LuczakNational Medical Institute of the Ministry of the Interior and Administration, Warsaw, Poland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Natural latex allergy poses significant risks in medicine due to widespread use of the material and potential for severe reactions. Aim: To examine latex allergy causes, clinical manifestations, and contemporary diagnostic approaches through systematic literature review. Methods: Systematic analysis of 67 publications published between 2019 and 2024, conducted from August to December 2024, using multiple databases, defined inclusion/exclusion criteria, and comparative content analysis. Results: Fresh latex comprises 60% water, 35% polyisoprene, and 5% proteins/lipids, with Hev b proteins being highly sensitising. Medical personnel demonstrate 5-17% allergy prevalence; industrial workers show up to 12% sensitisation. Key risk factors include atopy, tropical fruit cross-reactivity, and multiple childhood surgeries. Skin tests, specific IgE detection, and provocation tests demonstrate high diagnostic efficacy. Conclusions: Unified allergenicity assessment standards and enhanced regulatory control are essential. Transitioning to synthetic alternatives and improving early diagnostic protocols can reduce complications and enhance safety.

Indexed as

clinical manifestationsHev b allergensimmune responselatex–fruit syndromenatural rubber latex (NRL)sensitisationskin tests

Identifiers

PMID42621310
PMCPMC13487568

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.