ArticleTherapeutic advances in medical oncology2026
Efficacy and safety of different treatment regimens in patients with small cell lung cancer progressing from limited-stage to extensive-stage disease.
Article in Therapeutic advances in medical oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Limited-stage small cell lung cancer (LS-SCLC) frequently progresses to extensive-stage disease (ES-SCLC) after standard therapy. However, evidence regarding the efficacy and safety of various treatment regimens for this specific patient population remains limited. Objectives: This study aimed to evaluate the efficacy and safety of various treatment regimens among patients who progressed from LS-SCLC to ES-SCLC after standard chemoradiotherapy. Design: Survival analyses using propensity score matching (PSM) were conducted in patients with LS-SCLC who progressed to ES-SCLC to assess the efficacy and safety of multiple treatment regimens, especially immunotherapy. Methods: This retrospective study included 378 patients with LS-SCLC who progressed to ES-SCLC at Shandong Cancer Hospital from January 2018 to December 2024. After propensity score matching (PSM), patients were divided into immunotherapy and non-immunotherapy groups. Data on treatment regimens and clinical outcomes, including objective response rate (ORR), disease control rate (DCR), progression-free survival (PFS), and overall survival (OS), were collected. Kaplan-Meier analysis estimated PFS and OS, and Cox regression identified factors influencing OS. Results: Median overall survival (mOS) and median progression-free survival (mPFS) in the immunotherapy group were longer than those in the non-immunotherapy group (16.4 vs 12.3 months, P < 0.05; 5.3 vs 4.9 months, P < 0.05, respectively). In an exploratory subgroup analysis, platinum-based regimens were associated with longer OS only in patients with a treatment-free interval (TFI) of 3 months or longer (median 19.3 vs 12.5 months; HR = 0.65, 95% CI 0.44-0.95, P < 0.05). Conclusion: Our exploratory real-world data suggest that immunotherapy is associated with improved patient outcomes in patients with LS-SCLC who progress to ES-SCLC. Platinum-based regimens may be associated with better prognosis in the subgroup with a TFI of 3 months or longer. Given the exploratory nature, further prospective randomized trials are needed to confirm these observations.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.