ArticleArthroplasty today2026
Octenidine-Based Versus Chlorhexidine-Based Preoperative Skin Antisepsis in Primary Hip and Knee Arthroplasty.
Article in Arthroplasty today, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Surgical site infection (SSI) and periprosthetic joint infection (PJI) remain major complications after primary total hip arthroplasty (THA) and total knee arthroplasty (TKA). Preoperative antisepsis bundles are essential components of infection-prevention pathways; however, comparative data on octenidine-based vs chlorhexidine-based protocols remain limited. This study compared infectious and wound-related outcomes between these bundles in primary THA and TKA. Methods: This retrospective cohort study included 1767 consecutive patients who underwent primary THA or TKA between March 2015 and September 2024. Patients were stratified by antisepsis bundle: chlorhexidine-based group, 867 patients; and octenidine-based group, 900 patients. Baseline characteristics, American Society of Anesthesiologists class, comorbidities, procedure type, wound complications, SSI, PJI, readmission, and revision surgery were analyzed. Primary outcomes were 30-day superficial SSI, 90-day deep SSI/PJI, and 1-year PJI. Secondary outcomes included composite infectious and wound-related events. Between-group comparisons and adjusted analyses were performed where permitted. Results: Baseline characteristics were comparable. Thirty-day superficial SSI occurred in 0.8% of chlorhexidine patients and 1.1% of octenidine patients (Relative risk [RR], 1.38; 95% confidence interval (CI), 0.53-3.61; Conclusions: Octenidine-based preoperative antisepsis showed outcomes comparable to chlorhexidine-based antisepsis in primary THA and TKA.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.