Evidence map›Paper›PMID 42621228›Full record

ArticleInternational journal of cardiology. Heart & vasculature2026

Efficacy and safety of concomitant left atrial appendage closure and pulmonary vein isolation compared to left atrial appendage closure only - A meta-analysis.

Isabel Rattka, Christine Poch, Tanja Mews, Constantin Friesacher, Niklas Jurik, Eimo Martens, Karl-Ludwig Laugwitz, Alexander Steger, Manuel Rattka

Abstract read
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In one paragraph

Article in International journal of cardiology. Heart & vasculature, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Isabel RattkaSchool of Medicine and Health, Department of Clinical Medicine-Clinical Department for Cardiology, University Medical Centre, Technical University of Munich, Munich, Germany.
Christine PochSchool of Medicine and Health, Department of Clinical Medicine-Clinical Department for Cardiology, University Medical Centre, Technical University of Munich, Munich, Germany.
Tanja MewsSchool of Medicine and Health, Department of Clinical Medicine-Clinical Department for Cardiology, University Medical Centre, Technical University of Munich, Munich, Germany.
Constantin FriesacherSchool of Medicine and Health, Department of Clinical Medicine-Clinical Department for Cardiology, University Medical Centre, Technical University of Munich, Munich, Germany.
Niklas JurikSchool of Medicine and Health, Department of Clinical Medicine-Clinical Department for Cardiology, University Medical Centre, Technical University of Munich, Munich, Germany.
Eimo MartensSchool of Medicine and Health, Department of Clinical Medicine-Clinical Department for Cardiology, University Medical Centre, Technical University of Munich, Munich, Germany.
Karl-Ludwig LaugwitzSchool of Medicine and Health, Department of Clinical Medicine-Clinical Department for Cardiology, University Medical Centre, Technical University of Munich, Munich, Germany.
Alexander StegerSchool of Medicine and Health, Department of Clinical Medicine-Clinical Department for Cardiology, University Medical Centre, Technical University of Munich, Munich, Germany.
Manuel RattkaSchool of Medicine and Health, Department of Clinical Medicine-Clinical Department for Cardiology, University Medical Centre, Technical University of Munich, Munich, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Atrial fibrillation (AF) is associated with an increased risk of ischemic stroke, primarily originating from the left atrial appendage (LAA). Percutaneous LAA closure (LAAC) reduces appendage-borne thromboembolism, while pulmonary vein isolation (PVI) restores sinus rhythm. Observational data on the combined one-stop procedure are heterogeneous, and data on its risk-benefit profile remain scarce. Thus, a meta-analysis was performed to compare the efficacy and safety of combined LAAC+PVI versus LAAC-only. Methods: A structured systematic search of PubMed, MEDLINE, Scopus and Web of Science was performed for studies comparing outcomes of AF patients undergoing combined LAAC+PVI or LAAC-only. Results: Fifteen studies reporting data from 335,013 patients (11,839 LAAC+PVI; 323,174 LAAC-only) were included. Combined LAAC+PVI was associated with significantly fewer systemic thromboembolisms at follow-up (OR = 0.76, 95% CI = 0.60-0.96, I Conclusion: Combined LAAC+PVI was associated with fewer systemic thromboembolisms than LAAC-only, but a higher periprocedural risk of pericardial effusion requiring drainage and divergent temporal behaviour of peri-device leaks. Randomized controlled trials are warranted to confirm these findings.

Indexed as

ConcomitantLeft atrial appendage closurePericardial effusionPeri-device leakPulmonary vein isolationStroke

Identifiers

PMID42621228
PMCPMC13486899

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.