ArticleMolecular therapy. Advances2026
Ad5/52s fiber substitution alters Ad5 tropism, bioavailability, and plasma sensitivity.
Article in Molecular therapy. Advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Adenovirus type 5 (Ad5) is a well-established platform for gene transfer but relies on the coxsackie and adenovirus receptor (CAR), limiting efficacy in CAR-deficient tissues and influencing biodistribution through interactions with blood cells. Human adenovirus 52 (Ad52) encodes two fibers: a long CAR-binding fiber (F52L) and a short fiber (F52s) that engages sialylated glycoconjugates. Here, we engineered a chimeric Ad5/52s vector by replacing the Ad5 fiber with F52s. Ad5/52s production was initially inefficient due to delayed replication, but optimization of harvest timing markedly improved infectious titers and particle quality.
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