ArticleiScience2026
Expanding CIRdb, a comprehensive catalog of whole-exome sequencing data of Canary Islanders.
Article in iScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
The Canary Islanders exhibit a unique genetic admixture, comprising European (EUR), North African (NAF), and sub-Saharan African (SSA) ancestries. We comprehensively characterized the full spectrum of small genetic variation in this population based on whole-exome sequencing data to further develop CIRdb. Our results revealed 387,555 variants, of which 15.1% were previously unreported, and we prioritized novel putative pathogenic variants exhibiting enrichment in respiratory, cardiovascular, and metabolic disorders. Genetic differentiation patterns provided fine-grained insights into within-archipelago differentiation. We revealed an EUR genetic ancestry enrichment around the 17q21.31 inversion (a pleiotropic locus associated with pulmonary, infectious, and immunological diseases) and a candidate selective sweep shared by Canary Islanders and the NAF population around prune exopolyphosphatase 1 (
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