Evidence map›Paper›PMID 42621133›Full record

ArticleiScience2026

Brain circadian clock neurons drive fitness advantages in

Sae Aikawa, Shoichiro Tamura, Makiko Mimura, Taishi Yoshii

Abstract read
In one paragraph

Article in iScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Sae AikawaGraduate School of Environmental, Life, Natural Science and Technology, Okayama University, Okayama 700-8530, Japan.
Shoichiro TamuraGraduate School of Environmental, Life, Natural Science and Technology, Okayama University, Okayama 700-8530, Japan.
Makiko MimuraGraduate School of Environmental, Life, Natural Science and Technology, Okayama University, Okayama 700-8530, Japan.
Taishi YoshiiGraduate School of Environmental, Life, Natural Science and Technology, Okayama University, Okayama 700-8530, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The adaptive significance of circadian clocks is widely assumed due to their ubiquity; yet, direct empirical evidence remains scarce. Evaluating these benefits is often confounded by pleiotropic effects in conventional circadian null mutants. To address this, we selectively altered the circadian period exclusively within brain clock neurons in

Indexed as

activity rhythmsadaptive advantageclock neuronsDrosophilareproductive successresonance hypothesis

Identifiers

PMID42621133
PMCPMC13486361

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.