A surgically compatible shape memory alloy electroporation electrode for delivering DNA to the living retina.

Yu Zhang, Chendi Li, Anlan Zhang, Xin Wu, Huiting Zhao, Yuxin Li, Yuntao Hu, Zewen Wei

Abstract read

In one paragraph

Article in Materials today. Bio, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Yu ZhangDepartment of Biomedical Engineering, School of Medical Technology, Beijing Institute of Technology, Beijing, 100081, China.

Chendi LiEye Center, Beijing Tsinghua Changgung Hospital, School of Clinical Medicine, Tsinghua University, Beijing, 102218, China.

Anlan ZhangDepartment of Biomedical Engineering, School of Medical Technology, Beijing Institute of Technology, Beijing, 100081, China.

Xin WuDepartment of Biomedical Engineering, School of Medical Technology, Beijing Institute of Technology, Beijing, 100081, China.

Huiting ZhaoDepartment of Biomedical Engineering, School of Medical Technology, Beijing Institute of Technology, Beijing, 100081, China.

Yuxin LiShanghai Aier Eye Hospital, Shanghai, 200235, China.

Yuntao HuEye Center, Beijing Tsinghua Changgung Hospital, School of Clinical Medicine, Tsinghua University, Beijing, 102218, China.

Zewen WeiDepartment of Biomedical Engineering, School of Medical Technology, Beijing Institute of Technology, Beijing, 100081, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The successful application of adeno-associated virus (AAV)-mediated DNA delivery has opened a new era in the gene therapy of retinal diseases. Electroporation (EP) has the potential to avoid the drawbacks of AAV-mediated delivery, such as limited cargo size and unresolved safety concerns. Unfortunately, all reported EP devices are not compatible with standard ocular surgical procedures, preventing the clinical exploration of EP-mediated delivery of therapeutic DNA. To address this issue, a surgically compatible EP device has been developed for localized

Indexed as

Gene deliveryRetina electroporationShape memory alloy

Identifiers

PMID42621064

DOI10.1016/j.mtbio.2026.103522

PMCPMC13486314

What OpenQuestion holds

Textmetadata

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.