Evidence map›Paper›PMID 42621037›Full record

ArticlePhysics and imaging in radiation oncology2026

Deep learning-enhanced image registration for accelerating daily adaptive magnetic resonance imaging-guided prostate radiotherapy.

Cornel Zachiu, Gijsbert H Bol, Alexis N T J Kotte, Thomas Willigenburg, Matteo Maspero, Mark H F Savenije, Johannes C J de Boer, Jochem R N van der Voort van Zyp, Cornelis A T van den Berg, Bas W Raaymakers

Abstract read
In one paragraph

Article in Physics and imaging in radiation oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Cornel ZachiuDepartment of Radiotherapy, UMC Utrecht, Heidelberglaan 100, 3508 GA, The Netherlands.
Gijsbert H BolDepartment of Radiotherapy, UMC Utrecht, Heidelberglaan 100, 3508 GA, The Netherlands.
Alexis N T J KotteDepartment of Radiotherapy, UMC Utrecht, Heidelberglaan 100, 3508 GA, The Netherlands.
Thomas WilligenburgDepartment of Radiotherapy, UMC Utrecht, Heidelberglaan 100, 3508 GA, The Netherlands.
Matteo MasperoDepartment of Radiotherapy, UMC Utrecht, Heidelberglaan 100, 3508 GA, The Netherlands.
Mark H F SavenijeDepartment of Radiotherapy, UMC Utrecht, Heidelberglaan 100, 3508 GA, The Netherlands.
Johannes C J de BoerDepartment of Radiotherapy, UMC Utrecht, Heidelberglaan 100, 3508 GA, The Netherlands.
Jochem R N van der Voort van ZypDepartment of Radiotherapy, UMC Utrecht, Heidelberglaan 100, 3508 GA, The Netherlands.
Cornelis A T van den BergDepartment of Radiotherapy, UMC Utrecht, Heidelberglaan 100, 3508 GA, The Netherlands.
Bas W RaaymakersDepartment of Radiotherapy, UMC Utrecht, Heidelberglaan 100, 3508 GA, The Netherlands.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background and purpose: Daily auto-contouring remains a workflow bottleneck in magnetic resonance-guided adaptive prostate radiotherapy (MRgRT). This study proposes and clinically validates a novel deep learning-enhanced deformable image registration (DIR) solution to accelerate this critical step. Materials and Methods: A hybrid framework combining a 3D nnU-Net segmenting bladder/rectum on planning/daily MRI with an in-house DIR algorithm was implemented for 5-fraction prostate MRgRT ( Results: Evaluation following clinical introduction, has shown a median contouring time of Conclusions: The implemented solution demonstrated reliable, high-accuracy daily auto-contouring, significantly accelerating MRgRT workflows. It has become our institutional standard for prostate treatments. Future work will extend this approach to additional treatment sites and modalities.

Indexed as

Daily auto-contouringMR guidanceOnline adaptionProstate radiotherapy

Identifiers

PMID42621037
PMCPMC13486320

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.