ArticleFrontiers in medicine2026
Diagnostic accuracy and severity prediction of monocyte distribution width in sepsis: a retrospective study from the United Arab Emirates.
Article in Frontiers in medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Introduction: Monocyte distribution width (MDW) is an early sepsis biomarker derived from the routine complete blood count. Existing evidence is overwhelmingly from European, North American, and East Asian cohorts, with no published Middle Eastern data. We evaluated the diagnostic value of MDW for sepsis identification in a United Arab Emirates (UAE) tertiary care population, comparing it with procalcitonin (PCT), C-reactive protein (CRP), and quick Sequential Organ Failure Assessment (qSOFA). Methods: We retrospectively reviewed 140 adults admitted to Rashid Hospital, Dubai, with confirmed infections in 2024, classified by Sepsis-3 criteria as sepsis ( Results: Median MDW differed across groups: 27.6 (IQR 22.6-34.6) in sepsis, 28.2 (25.4-33.0) in septic shock, and 24.0 (19.9-27.6) in other infections ( Discussion: In this first UAE cohort, MDW behaved consistently with international evidence. Standalone discrimination was moderate, but MDW + qSOFA matched a CRP-based composite at no additional sample/reagent cost. As the comparator group comprised only infected patients, these AUCs reflect an infection-enriched design and are expected to be lower than in unselected emergency-department populations. Region-specific cutoffs and prospective multicenter Gulf evaluations are required for further evaluation.
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