ArticleFrontiers in aging neuroscience2026
Translating peripheral blood biomarkers into Alzheimer's disease care: an exploratory dual-pathway model of immune and viral dynamics in behavioral and psychological symptoms of dementia.
Article in Frontiers in aging neuroscience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Behavioral and psychological symptoms of dementia (BPSD) critically complicate Alzheimer's disease care, yet the precise biological correlates for highly heterogeneous symptom domains remain largely unexplored. Objective: To investigate an exploratory "dual-pathway framework" to map how macroscopic immunosenescence and elevated latent viral antibody titers parallelly correlate with distinct neurobehavioral phenotypes. Methods: We evaluated 103 older adults diagnosed with mild cognitive impairment (n = 40) or probable Alzheimer's disease ( Results: Macroscopic immunosenescence, reflected by an elevated CD4/CD8 ratio (>1.58), differentiated Alzheimer's disease from mild cognitive impairment ( Conclusion: Behavioral and psychological symptoms of dementia are associated with an exploratory dual-pathway model. Elevated viral antibody titers act as an immunological priming factor associated with symptom occurrence, whereas the reduction of adaptive immune reserves continuously modulates the global neuropsychiatric severity in Alzheimer's disease.
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