ReviewFrontiers in neurology2026
A case of neonatal herpes simplex virus type 2 encephalitis with
Review in Frontiers in neurology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Neonatal herpes simplex virus type 2 (HSV-2) encephalitis frequently manifests with atypical clinical features, which complicates its early identification. Given the challenge of controlling the infant's seizures, whole exome sequencing was conducted to rule out genetic disorders like early-onset epileptic encephalopathy; this process incidentally revealed a variation in the Case presentation: A 17-day-old female presented with fever and frequent convulsions 15 days after birth. Cranial MRI showed meningoencephalitis, and funduscopy revealed infectious retinopathy. Exome sequencing identified a heterozygous Conclusion: In infants with fever and convulsions showing poor response to empirical treatment, cerebrospinal fluid mNGS is strongly recommended for early diagnosis. Further research is needed on the pathogenic role of
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