ArticleJCPP advances2026
Childhood adversity and psychotic-like experiences in adolescence: Investigating a pathway via disrupted pubertal and grey matter development.
Article in JCPP advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Childhood adversity increases psychosis risk, but the biological mechanisms responsible remain elusive. A possible but underexplored pathway involves altered pubertal and grey matter (GM) development. Methods: In youth from the Adolescent Brain Cognitive Development study ( Results: Associations were found between all adversity types and greater PLEs, of which most were mediated by earlier pubertal timing and/or slower tempo. Mediation effects tended to be stronger in females, and for socioeconomic deprivation pathways. Results did not support the presence of serial mediation pathways from adversity to PLEs via puberty-related GM variation. Conclusion: Findings suggest that disruption to pubertal development may contribute to the link between adversity and psychosis risk, but not by altering GM development. Investigating puberty alongside alternative biological systems may help contextualise our findings.
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