Evidence map›Paper›PMID 42620929›Full record

ArticleBioactive materials2027

Synthetic β-amino acid polymer promoting keratocyte adhesion and corneal regeneration.

Mingjiao Chen, Qi Chen, Jiawei Gu, Guojian Liu, Xia Ding, Yu Yu, Ling Li, Donghui Zhang, Haodong Zhang, Ming Lin and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bioactive materials, 2027. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Mingjiao ChenDepartment of Ophthalmology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, State Key Laboratory of Eye Health, Shanghai, 200011, China.
Qi ChenState Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai, 200237, China.
Jiawei GuState Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai, 200237, China.
Guojian LiuState Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai, 200237, China.
Xia DingDepartment of Ophthalmology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, State Key Laboratory of Eye Health, Shanghai, 200011, China.
Yu YuDepartment of Ophthalmology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, State Key Laboratory of Eye Health, Shanghai, 200011, China.
Ling LiState Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai, 200237, China.
Donghui ZhangSuzhou Institute of Biomedical Engineering and Technology, Chinese Academy of Sciences, Suzhou, 215163, China.
Haodong ZhangState Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai, 200237, China.
Ming LinDepartment of Ophthalmology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, State Key Laboratory of Eye Health, Shanghai, 200011, China.
Jin LiDepartment of Ophthalmology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, State Key Laboratory of Eye Health, Shanghai, 200011, China.
Runhui LiuState Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai, 200237, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Corneal damage ranks among the leading causes of visual impairment globally. Given the prevalence of corneal diseases and challenges of donor cornea shortages and immune rejection, there is an urgent need to develop alternative materials for corneal repair. Although decellular corneal stroma and hydrogels modified with extracellular matrix (ECM) proteins/peptides were extensively used for corneal repair, they face the challenges such as batch to batch variation and easy proteolysis. Aiming to address these challenges, we report that the function stable and synthesis controllable β-amino acid polymer promotes keratocyte adhesion comparable to the cell adhesion gold standard RGD peptide. The optimal polymer (DM

Indexed as

Cell adhesionCorneal regenerationHyaluronic acid hydrogelRGD peptideβ-amino acid polymer

Identifiers

PMID42620929
PMCPMC13487277

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.