ArticleFrontiers in neurology2026
The influence of refined enteral nutrition intervention on nutritional status and feeding intolerance in critically ill stroke patients.
Article in Frontiers in neurology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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6 authors.
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Abstract
Background: Critically ill stroke patients frequently experience dysphagia, posing challenges to adequate nutrient intake. Furthermore, these patients often remain in a prolonged state of high stress, hypermetabolism, and reduced immunity. While early enteral nutritional support is crucial, feeding intolerance remains a prevalent issue. This study evaluates the real-world impact of a refined enteral nutrition (EN) intervention on EN outcomes. Objective: To investigate the effect of a refined enteral nutrition intervention on nutritional status and feeding intolerance in critically ill stroke patients. Methods: This quasi-experimental study employed a pre-post design. The control group ( Results: Post-intervention albumin levels were significantly higher in the Intervention group (40.69 ± 1.88 g/L) compared to the Control group (38.92 ± 1.21 g/L; Conclusion: The refined enteral nutrition intervention was associated with improved short-term nutritional status and reduced incidence of feeding intolerance in critically ill stroke patients. However, due to the quasi-experimental design historical controls, the inclusion of adjunctive therapies with unproven efficacy, and the lack of long-term outcome data (including 30-day mortality and functional recovery), categorical claims about improved prognosis cannot be made. The observed benefits may be associated with the comprehensive nursing protocol rather than the refined EN intervention alone and our findings should be interpreted as demonstrating an association rather than a causal relationship. Large-scale, multicenter randomized controlled trials are needed to confirm these findings.
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