ArticleFrontiers in nutrition2026
Associations of six adiposity indices with incident back pain and the mediating role of the triglyceride-glucose index: prospective findings from the UK biobank.
Article in Frontiers in nutrition, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Back pain is now recognized as a major contributor to global disability. While the correlation between BMI and back pain risk has been confirmed, there is a lack of research on the association between obesity indices that accurately reflect fat distribution and back pain risk. Additionally, no studies have investigated whether the association is modified by any genetic factor, and remains unclear about the meditating role of triglyceride glucose (TyG). Methods: This prospective study involved participants from the UK Biobank without back pain at baseline. Cox regressions were utilized to analyze the relationships between BMI, waist circumference, hip circumference, waist-to-hip ratio (WHR), waist-to-height ratio (WHtR), and A Body Shape Index (ABSI) with back pain risk. The interactions between these obesity indices and genetic risk were also examined. Additionally, we investigated the meditating role of TyG for further understanding. Results: The multivariate Cox regression indicated that high levels of obesity indices were significantly correlated with back pain [BMI: hazard ratio (HR) = 1.45, 95% confidence interval (CI): 1.40-1.49, Conclusion: Obesity is significantly and positively related to back pain risk with TyG playing a partial mediating role, but no significant interaction was observed between obesity and genetic susceptibility. As a result, focusing on obesity and metabolic dysfunction in obese individuals is crucial for reducing the risk of back pain.
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