Evidence map›Paper›PMID 42620911›Full record

ArticleMaterials today. Bio2026

PDL1-driven self-amplifying drug homing with immune homeostasis restoration.

Xiaoshuang Wang, Wanze Zhang, Chenxi Zhao, Di Wang, Yingyu Zhang, Jianfeng Wang, Xinyu Li, Jinbao Wang, Xuemei Han, Fuxin Xue and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Materials today. Bio, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Xiaoshuang WangChina-Japan Union Hospital of Jilin University, Changchun, 130033, China.
Wanze ZhangChina-Japan Union Hospital of Jilin University, Changchun, 130033, China.
Chenxi ZhaoChina-Japan Union Hospital of Jilin University, Changchun, 130033, China.
Di WangChina-Japan Union Hospital of Jilin University, Changchun, 130033, China.
Yingyu ZhangChina-Japan Union Hospital of Jilin University, Changchun, 130033, China.
Jianfeng WangChina-Japan Union Hospital of Jilin University, Changchun, 130033, China.
Xinyu LiThe First Hospital of Jilin University, Changchun, 130000, China.
Jinbao WangChina-Japan Union Hospital of Jilin University, Changchun, 130033, China.
Xuemei HanChina-Japan Union Hospital of Jilin University, Changchun, 130033, China.
Fuxin XueChina-Japan Union Hospital of Jilin University, Changchun, 130033, China.
Linlin LiuChina-Japan Union Hospital of Jilin University, Changchun, 130033, China.
Zhaohui TangKey Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Antibody-decorated nanomedicines can selectively deliver drugs to tumors. However, their targeting efficiency diminishes as the density of the target antigen decreases. To address this limitation, this study developed a PDL1-driven, self-sustaining feedback drug-homing nanoparticle, termed aPDL1-PLG-DOX nanoparticles (aPDL1-P-DOX). This construction was prepared by loading doxorubicin (DOX) into a phenylboronic acid-bearing poly(

Indexed as

Drug deliveryImmunogenic cell deathROS sensitiveSelf-sustaining feedbackTumor immune homeostasis

Identifiers

PMID42620911
PMCPMC13487320

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.