ArticleFrontiers in pediatrics2026
Correlation analysis of cyclosporine A trough concentration with hematological and biochemical parameters: a retrospective study in pediatric aplastic anemia.
Article in Frontiers in pediatrics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Not yet cited in PubMed.
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Abstract
Aplastic anemia (AA) is a life-threatening pediatric hematological disorder requiring immunosuppressive therapy with cyclosporine A (CsA), which has a narrow therapeutic window and significant interindividual variability. The relationship between CsA trough concentration and routine laboratory markers in children remains poorly defined. This retrospective study enrolled 14 pediatric AA patients (70 paired samples) followed over 12 months. Associations between CsA trough concentration and hematological, hepatic, and renal parameters were analyzed using linear mixed-effects models with random intercepts to account for repeated measures, complemented by time-stratified Pearson correlations. Benjamini-Hochberg false discovery rate (FDR) correction was applied for multiple comparisons. CsA trough concentration showed a significant positive association with blood urea nitrogen (β = 0.012, 95% CI: 0.007-0.017,
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