Evidence map›Paper›PMID 42620768›Full record

ArticleiScience2026

Mechanism of injury and fracture status influence outcomes after central cord injury.

Karlo M Pedro, Mohammed Ali Alvi, Kathleen Zang, Christopher Lozano, Jetan H Badhiwala, Jefferson R Wilson, James S Harrop, James D Guest, Bizhan Aarabi, Christopher I Shaffrey and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Karlo M PedroDivision of Neurosurgery and Spine Program, Department of Surgery, University of Toronto, Toronto, ON, Canada.
Mohammed Ali AlviDivision of Neurosurgery and Spine Program, Department of Surgery, University of Toronto, Toronto, ON, Canada.
Kathleen ZangDivision of Neurosurgery, Krembil Neuroscience Centre, Toronto Western Hospital, University Health Network, Toronto, ON, Canada.
Christopher LozanoDivision of Neurosurgery and Spine Program, Department of Surgery, University of Toronto, Toronto, ON, Canada.
Jetan H BadhiwalaDivision of Neurosurgery and Spine Program, Department of Surgery, University of Toronto, Toronto, ON, Canada.
Jefferson R WilsonInstitute for Health Policy, Management and Evaluation, University of Toronto, Toronto, ON, Canada.
James S HarropDepartment of Neurological Surgery, Thomas Jefferson University, Philadelphia, PA, USA.
James D GuestDepartment of Neurosurgery and The Miami Project to Cure Paralysis, The Miller School of Medicine, University of Miami, Miami, FL, USA.
Bizhan AarabiDepartment of Neurosurgery, University of Maryland School of Medicine, Baltimore, MD, USA.
Christopher I ShaffreyDepartment of Neurosurgery, Duke University Medical Center, Durham, NC, USA.
Michael G FehlingsDivision of Neurosurgery and Spine Program, Department of Surgery, University of Toronto, Toronto, ON, Canada.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Central cord syndrome (CCS) is the most common form of incomplete cervical spinal cord injury (SCI), yet its optimal management remains controversial. We examined whether stratifying CCS by injury stability improves treatment assessment. CCS was defined as an American Spinal Injury Association Impairment Scale (AIS) C/D cervical SCI with a ≥5-point lower-upper extremity motor score difference and classified as CCS-stable (CCS-S) or -unstable (CCS-U) based on the absence or presence of fracture/dislocation. Functional recovery at 1 year was assessed using the functional independence measure (FIM) motor score. Among 291 patients, 131 (45%) had CCS-S. These patients were older and more frequently sustained fall-related injuries. In the propensity score-matched cohort, CCS-S showed greater functional improvement than CCS-U, although the difference was attenuated after multiplicity adjustment (mean difference 5.46 points,

Indexed as

central cord syndromefunctional recoveryspinal cord injuryunstable central cord syndromeupper extremity motor score

Identifiers

PMID42620768
PMCPMC13486855

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.