Evidence map›Paper›PMID 42620761›Full record

ArticleiScience2026

Engineered HMGB1 construct with tandem Box B domains promotes tissue regeneration without potential for inflammation.

Álvaro Viñals Guitart, Carl Lee, Ana Isabel Espírito Santo, Jia-Ling Ruan, Shih-Hsuan Mao, Lynn William, Christina Redfield, Oleg Fedorov, Nicola A Burgess-Brown, Wyatt W Yue and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Álvaro Viñals GuitartCentre for Medicines Discovery, University of Oxford, Oxford, UK.
Carl LeeKennedy Institute of Rheumatology, University of Oxford, Oxford, UK.
Ana Isabel Espírito SantoKennedy Institute of Rheumatology, University of Oxford, Oxford, UK.
Jia-Ling RuanDepartment of Oncology, University of Oxford, Oxford, UK.
Shih-Hsuan MaoKennedy Institute of Rheumatology, University of Oxford, Oxford, UK.
Lynn WilliamKennedy Institute of Rheumatology, University of Oxford, Oxford, UK.
Christina RedfieldDepartment of Biochemistry, University of Oxford, Oxford, UK.
Oleg FedorovCentre for Medicines Discovery, University of Oxford, Oxford, UK.
Nicola A Burgess-BrownCentre for Medicines Discovery, University of Oxford, Oxford, UK.
Wyatt W YueCentre for Medicines Discovery, University of Oxford, Oxford, UK.
Jagdeep NanchahalKennedy Institute of Rheumatology, University of Oxford, Oxford, UK.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Fully reduced high-mobility group box 1 (HMGB1) binds CXCL12 and signals via CXCR4 when released into the extracellular space. It acts as a chemokine and transitions stem cells from quiescent G

Indexed as

CXCL12-CXCR4 axisHMGB1InflammationTissue regeneration

Identifiers

PMID42620761
PMCPMC13486833

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.