Evidence map›Paper›PMID 42620751›Full record

ArticleGenes & diseases2026

Age-dependent mitochondrial toxicity in renal stem cells: A precise 3D silk matrix model.

Pengfei Yu, Huifen Ding, Jian-Xing Ma, Zhongping Duan, Yu Chen, Anthony Atala, Yuanyuan Zhang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Genes & diseases, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Pengfei YuThe Fourth Department of Liver Disease, Beijing YouAn Hospital, Capital Medical University, Beijing 100069, China.
Huifen DingWake Forest Institute for Regenerative Medicine, Wake Forest University Health Sciences, Winston-Salem, North Carolina 27101, USA.
Jian-Xing MaDepartment of Biochemistry, Wake Forest University Health Sciences, Winston-Salem, North Carolina 27157, USA.
Zhongping DuanThe Fourth Department of Liver Disease, Beijing YouAn Hospital, Capital Medical University, Beijing 100069, China.
Yu ChenThe Fourth Department of Liver Disease, Beijing YouAn Hospital, Capital Medical University, Beijing 100069, China.
Anthony AtalaWake Forest Institute for Regenerative Medicine, Wake Forest University Health Sciences, Winston-Salem, North Carolina 27101, USA.
Yuanyuan ZhangWake Forest Institute for Regenerative Medicine, Wake Forest University Health Sciences, Winston-Salem, North Carolina 27101, USA.

Funding

3D Culture Systems Of Urine-Derived Stem Cell For NTRI-Induced Mitotoxicity AssessmentR21AI152832 · NIAID · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI ZHANG, YUANYUAN NO · 2020 to 2021
$426k
Silk Fibers-Assisted 3D System for Large-Scale Culture of Human Urine-Derived Stem Cells Suitable for Late Mitotoxicity TestingR03AI165170 · NIAID · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI ZHANG, YUANYUAN NO · 2021 to 2022
$155k
NIAID NIH HHS R03 AI165170NIAID NIH HHS R21 AI152832
6 · The paper itself

Abstract

Aging is a significant risk factor for drug-induced kidney injury, underscoring the need for advanced preclinical models. The impact of age on the susceptibility of human primary kidney stem cells to drug-induced mitochondrial toxicity remains largely uncharacterized. To address this gap, we employed a well-established

Indexed as

3D cell cultureAgingDrug-induced kidney injuryMitochondrial function parametersRenal stem cellsSilk matrixTenofovir

Identifiers

PMID42620751
PMCPMC13486992

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.