Evidence map›Paper›PMID 42620748›Full record

ArticleFrontiers in immunology2026

GFI1 as a novel regulator of γδ T cell development and the IL-17/IFN-γ lineage commitment.

Jennifer Fraszczak, David Obwegs, Kaifee Arman, Tanja Muralt, Bavanitha Thurairajah, Ève Mallet Gauthier, Irah L King, Heather J Melichar, Sagar, Tarik Möröy

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In one paragraph

Article in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Jennifer FraszczakInstitut de recherches cliniques de Montréal (IRCM), Montréal, QC, Canada.
David ObwegsDepartment of Medicine II (Gastroenterology, Hepatology, Endocrinology, and Infectious Diseases), Freiburg University Medical Center, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
Kaifee ArmanInstitut de recherches cliniques de Montréal (IRCM), Montréal, QC, Canada.
Tanja MuraltInstitut de recherches cliniques de Montréal (IRCM), Montréal, QC, Canada.
Bavanitha ThurairajahMeakins-Christie Laboratories, Research Institute of the McGill University Health Centre, Montreal, QC, Canada.
Ève Mallet GauthierDepartment of Microbiology and Immunology, McGill University, Montreal, QC, Canada.
Irah L KingMeakins-Christie Laboratories, Research Institute of the McGill University Health Centre, Montreal, QC, Canada.
Heather J MelicharDepartment of Microbiology and Immunology, McGill University, Montreal, QC, Canada.
SagarDepartment of Medicine II (Gastroenterology, Hepatology, Endocrinology, and Infectious Diseases), Freiburg University Medical Center, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
Tarik MöröyInstitut de recherches cliniques de Montréal (IRCM), Montréal, QC, Canada.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

GFI1 is a DNA-binding transcription factor that regulates the commitment of hematopoietic precursors to myeloid and lymphoid lineages. Here we report that GFI1 is expressed in γδ T cells and restricts the cellularity of RORγt

Indexed as

Cell LineageDNA-Binding ProteinsInterferon-gammaInterleukin-17Receptors, Antigen, T-Cell, gamma-deltaT-Lymphocyte SubsetsTranscription FactorsAnimalsCell DifferentiationMiceMice, Inbred C57BLMice, KnockoutNuclear Receptor Subfamily 1, Group F, Member 3Proto-Oncogene Proteins c-mafDNA-Binding ProteinsGfi1 protein, mouseInterferon-gammaInterleukin-17Nuclear Receptor Subfamily 1, Group F, Member 3Proto-Oncogene Proteins c-mafReceptors, Antigen, T-Cell, gamma-deltaTranscription Factorsallergyc-MAFgamma delta T cellsGFI1IL-17pre T cell development

Identifiers

PMID42620748
PMCPMC13485770

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.