Evidence map›Paper›PMID 42620741›Full record

ArticleiScience2026

Yuwen Wang, Ziyu Xiong, Qile Ye, Ying Li, Dongdong Zhang, Wenzhong Du, Cong Yan, Guofu Li, Zifeng Dai, Jingwei Li and 8 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Yuwen WangDepartment of Neurosurgery, The First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, China.
Ziyu XiongDepartment of Neurosurgery, The First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, China.
Qile YeDepartment of Critical Care Medicine, The Second Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, China.
Ying LiDepartment of Neurosurgery, The First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, China.
Dongdong ZhangDepartment of Neurosurgery, The First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, China.
Wenzhong DuDepartment of Neurosurgery, The First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, China.
Cong YanDepartment of Neurosurgery, The First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, China.
Guofu LiDepartment of Neurosurgery, Harbin Medical University Cancer Hospital, Harbin, Heilongjiang, China.
Zifeng DaiDepartment of Neurosurgery, The First Affiliated Hospital of Ningbo University, Ningbo, Zhejiang, China.
Jingwei LiDepartment of Neurosurgery, The First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, China.
Yongqing YeDepartment of Neurosurgery, The First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, China.
Chunyang MenDepartment of Neurosurgery, The First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, China.
Qianpeng DuanDepartment of Neurosurgery, The First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, China.
Rui BiDepartment of Neurosurgery, The First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, China.
Jiayu SongDepartment of Cranial Oncology Radiotherapy, Harbin Medical University Cancer Hospital, Harbin, Heilongjiang, China.
Silengtu HuDepartment of Neurosurgery, The First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, China.
Xia ZhaoDepartment of Neurosurgery, The First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, China.
Changbin ShiDepartment of Neurosurgery, The First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cerebral cavernous malformations (CCMs) are cerebrovascular lesions that can be influenced by genetic alterations affecting endothelial signaling. Here, we investigated how RASA1 deficiency modifies CCM progression using bioinformatic analyses, hCMEC/D3 endothelial knockdown and rescue models, Seahorse metabolic profiling, Ras-GTP pull-down assays, and a PDCD10-deficient mouse model with endothelial Rasa1 knockdown. RASA1 deficiency promoted endothelial proliferation, reduced ZO-1 expression, shifted energy metabolism from oxidative phosphorylation toward glycolysis, and activated Ras/Raf/MAPK signaling. RASA1 rescue or pharmacological Ras inhibition with RMC-7977 partially reversed these abnormalities

Indexed as

metabolic reprogrammingRASA1Ras/Raf/MAPK pathwaysporadic cerebral cavernous malformationsvascular endothelial proliferation

Identifiers

PMID42620741
PMCPMC13486854

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.