Evidence map›Paper›PMID 42620696›Full record

ArticleAsian journal of pharmaceutical sciences2026

Janus microneedles enabling orderly vitiligo treatment through spatiotemporal sequential promoting melanogenesis to transfer

Yan Tang, Tiantian Liu, Chuan Wang, Jiajun Xu, Guozhi Zhong, Qian Jing, Jingxin Liu, Fei Gao, Rujing Wang, Mengnan Zhao and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Asian journal of pharmaceutical sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Yan TangChinese Medicine Germplasm Resources Innovation and Effective Uses Key Laboratory of Sichuan Province, College of Modern Chinese Medicine Industry, School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China.
Tiantian LiuChinese Medicine Germplasm Resources Innovation and Effective Uses Key Laboratory of Sichuan Province, College of Modern Chinese Medicine Industry, School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China.
Chuan WangChinese Medicine Germplasm Resources Innovation and Effective Uses Key Laboratory of Sichuan Province, College of Modern Chinese Medicine Industry, School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China.
Jiajun XuChinese Medicine Germplasm Resources Innovation and Effective Uses Key Laboratory of Sichuan Province, College of Modern Chinese Medicine Industry, School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China.
Guozhi ZhongChinese Medicine Germplasm Resources Innovation and Effective Uses Key Laboratory of Sichuan Province, College of Modern Chinese Medicine Industry, School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China.
Qian JingChinese Medicine Germplasm Resources Innovation and Effective Uses Key Laboratory of Sichuan Province, College of Modern Chinese Medicine Industry, School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China.
Jingxin LiuInstitute of International Education, School of Medicine, Sechenov University, Moscow 119991, Russia.
Fei GaoChinese Medicine Germplasm Resources Innovation and Effective Uses Key Laboratory of Sichuan Province, College of Modern Chinese Medicine Industry, School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China.
Rujing WangSchool of Basic Medical Sciences, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China.
Mengnan ZhaoChinese Medicine Germplasm Resources Innovation and Effective Uses Key Laboratory of Sichuan Province, College of Modern Chinese Medicine Industry, School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China.
Sanjun ShiChinese Medicine Germplasm Resources Innovation and Effective Uses Key Laboratory of Sichuan Province, College of Modern Chinese Medicine Industry, School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Vitiligo is characterized by a complex pathogenesis involving multiple factors, necessitating therapeutic strategies that simultaneously achieve immune regulation, melanocyte regeneration, and melanosome transfer modulation. Here, we designed a Janus microneedle (Janus MN) based on a core-shell bilayer structure, inspired by the melanin metabolism pathway and the stratified architecture of the skin. The shell of the MN was loaded with a complex of hypericin-assembled nanoparticles (HY-NPs) and astragalus polysaccharides, which preferentially dissolve in the epidermal hair follicle region and basal layer. This intervention ameliorated the microenvironment by scavenging reactive oxygen species and inhibiting CD8

Indexed as

Hypericin-assembled nanoparticlesJanus microneedleRepair-regeneration-transfer spatiotemporal sequenceTrypsinVitiligo

Identifiers

PMID42620696
PMCPMC13485625

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.