Evidence map›Paper›PMID 42620644›Full record

ReviewEULAR rheumatology open2026

Anti-inflammatory approaches in cancer immunotherapy-induced autoimmunity.

Robert Zeiser

Abstract readReview
In one paragraph

Review in EULAR rheumatology open, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author.

Robert ZeiserDepartment of Medicine I, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cancer immunotherapy, including allogeneic haematopoietic cell transplantation, infusion of chimeric antigen receptor T (CAR-T) cells, bispecific antibodies, and immune checkpoint inhibitors (ICIs), has revolutionised the treatment of cancer. However, therapy resistance and immune-mediated side effects reduce the overall success. Recent developments in these 2 areas were reported at the 2026 ATT conference. Treatment of immune effector cell-associated neurotoxicity syndrome (ICANS) using transforming growth factor β (TGFβ)-activated kinase-1 (TAK1)-NF-κB-p38 mitogen-activated protein kinase (MAPK) pathway inhibition was shown to be effective in preclinical models. TAK1 inhibition reduced microglia activation and improved neurocognitive function after CAR19 T-cell transfer. This review discusses new developments in the fields of ICANS, graft-vs-host disease (GVHD), and ICI-mediated side effects.

Identifiers

PMID42620644
PMCPMC13485635

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.