ReviewBiophysical reviews2026
The thin line between biochemistry and structure where myosin super relaxed state lies.
Review in Biophysical reviews, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This short review acknowledges the scientific contribution of Roger Cooke and colleagues, who first introduced the idea of two different biochemical states in resting skeletal muscle thick filament. In a seminal paper published in 2010, the state defined as myosin "super relaxed state" (SRX) has been proposed as the biochemical counterpart of the structural motif named interacting head motif (IHM). This connection has been challenged and revised multiple times, leading to misunderstandings and improper assumptions. In this review, we discuss the recent history of the structure-biochemistry relationship associated with resting myosin thick filament, its current interpretation, and how this is possibly related to future myosin resting state studies.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.