ArticleFrontiers in bioengineering and biotechnology2026
Fabrication of a visible light photocrosslinkable κ-carrageenan-gelatin hydrogel patch to aid in wound healing applications.
Article in Frontiers in bioengineering and biotechnology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
A delay in wound healing significantly impacts a patient's quality of life. Although numerous materials have been developed for healing strategies, there remains a need to create a patient-friendly, patient-specific, and biocompatible product for the market. Biopolymer-based hydrogel dressings significantly influence wound healing by mimicking the extracellular matrix, promoting cell growth, regulating moisture levels, and preventing infection. In this study, biopolymers such as κ-carrageenan (κ-Ca) and gelatin (Gel) were chemically modified with methacrylic anhydride (MA) to produce photocurable κ-carrageenan methacrylate (κ-Ca-MA) and gelatin methacrylate (Gel-MA). A hydrogel patch was subsequently fabricated using visible-light photocrosslinking for wound-healing applications. The fabricated photocrosslinked composite hydrogel patch (PCHP) was comprehensively characterized with respect to its morphological structure, swelling, degradation behavior, and viscoelastic properties. The fabricated PCHP demonstrated gel-like behavior, good stability, and shear-thinning properties. Compression testing on PCHP revealed a compressive modulus of 234-239 kPa, demonstrating adequate mechanical integrity for wound-site application. Additionally, antibiotic-loaded PCHPs demonstrated slow, sustained antibiotic release with efficient bactericidal activity against
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