Evidence map›Paper›PMID 42620556›Full record

Observational studyFrontiers in immunology2026

Prospective subtyping identifies an association between high pretreatment levels of DEspR

Victoria L M Herrera, Kiana Mahdaviani, Jacqueline Choi, Sin-Han Chen, Eliot Gunn, Kurtis Stadnicki, Anais Mortazavi-Zadeh, Judith J Lok, Umit Tapan, Nelson Ruiz-Opazo

Abstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Victoria L M HerreraWhitaker Cardiovascular Institute, Chobanian & Avedisian School of Medicine, Boston University, Boston, MA, United States.
Kiana MahdavianiDepartment of Medicine, Boston Medical Center, Boston, MA, United States.
Jacqueline ChoiWhitaker Cardiovascular Institute, Chobanian & Avedisian School of Medicine, Boston University, Boston, MA, United States.
Sin-Han ChenDepartment of Medicine, Boston Medical Center, Boston, MA, United States.
Eliot GunnWhitaker Cardiovascular Institute, Chobanian & Avedisian School of Medicine, Boston University, Boston, MA, United States.
Kurtis StadnickiDepartment of Medicine, Boston Medical Center, Boston, MA, United States.
Anais Mortazavi-ZadehDepartment of Medicine, Boston Medical Center, Boston, MA, United States.
Judith J LokDepartment of Mathematics and Statistics, Boston University, Boston, MA, United States.
Umit TapanDepartment of Medicine, Boston Medical Center, Boston, MA, United States.
Nelson Ruiz-OpazoWhitaker Cardiovascular Institute, Chobanian & Avedisian School of Medicine, Boston University, Boston, MA, United States.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: High neutrophil-lymphocyte ratio (NLR) and neutrophil extracellular traps (NETs) are associated with poor overall survival in many cancers but are currently remain without safe effective therapy until subtype elucidation identifies a targetable molecular subtype whose inhibition will not compromise homeostatic pathogen defense. We tested the hypothesis that increased circulating NET-forming neutrophils (NET Methods: In a prospective observational study, we subtyped neutrophils by flow cytometry and NET Results: In 10 patients with mNSCLC, immunosuppressive PDL1 Conclusions: These data identify the DEspR

Indexed as

Carcinoma, Non-Small-Cell LungCell-Derived MicroparticlesExtracellular TrapsLung NeoplasmsNeutrophilsAgedFemaleHumansImmunotherapyInflammationMaleMiddle AgedProspective Studieschemo-immunotherapyDEspRmetastatic NSCLCmicrovesiclesNET-formationneutrophil extracellular trapsneutrophil subtypesPDL1+ neutrophils

Identifiers

PMID42620556
PMCPMC13485590

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.