ArticleFrontiers in nutrition2026
Association between non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio and sarcopenia with mediating role of triglyceride glucose-related indices: a cohort study in Chinese elderly adults.
Article in Frontiers in nutrition, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: The present study aims to investigate the association and dose-response relationship between the non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio (NHHR) and sarcopenia in elderly adults. The ultimate objective is to thereby clarify its predictive value for sarcopenia risk. Methods: A cross-sectional study was conducted using data from the cohort of 368 elderly individuals aged 60 years and over, as part of the Second Affiliated Hospital of Anhui Medical University. A prospective cohort study was also conducted using CHARLS data, encompassing 3,152 elderly individuals aged 60 years and over, with no instances of sarcopenia at the initial baseline. The median follow-up period for this study is 4.5 years. The association was analyzed using both logistic regression and Cox proportional hazards regression, with the results of this analysis subsequently validated by restricted cubic spline (RCS) analysis and subgroup analysis. Subsequently, the mediating role of the triglyceride glucose (TyG)-related indices was elucidated through mediation analysis. Results: Following the adjustment of confounding factors, a unit increase in NHHR was observed to be associated with a 31% reduction in sarcopenia risk in cross-sectional studies (OR = 0.69, 95% CI: 0.56-0.86, P < 0.001). In prospective cohort studies, the risk of sarcopenia decreased by 37% (HR = 0.63, 95% CI: 0.51-0.77, Conclusion: NHHR is significantly negatively correlated with the risk of sarcopenia in Chinese elderly adults and may serve as a potential biomarker for sarcopenia risk stratification. TyG-related indicators play a partial mediating role in this association.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.