ArticleFrontiers in medicine2026
A tNGS-based comparative study on clinical features and co-detection profiles of hospitalized children with influenza A and B viruses.
Article in Frontiers in medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Objectives: This study aimed to characterize the clinical and epidemiological features of hospitalized children with IBV and compare them with those of influenza A virus (IAV). Methods: We enrolled 10,143 pediatric inpatients with ARI between April 2021 and December 2024. Pathogen screening was conducted using targeted next-generation sequencing. Multivariable logistic regression was performed to identify independent predictors for respiratory support requirements. Results: IBV was detected in 198 children (2.0%). Compared to children with IAV ( Conclusion: IBV and IAV show similar age distributions and comparably high polymicrobial detection rates in hospitalized children. Importantly, multivariable analysis unmasked that IBV infection independently predicted a higher requirement for respiratory support than IAV, with younger age and female sex identifying particularly vulnerable cohorts. Clinicians should maintain high vigilance for respiratory progression in pediatric IBV inpatients.
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