Evidence map›Paper›PMID 42620491›Full record

ArticleFrontiers in plant science2026

Grapevine exarcerbates the virulence of

Idir Saber, Larissa Zeltner-Heck, Laëtitia Parent, Simon Remy, Anthony Abou Dib, Jean-Hugues Renault, Jochen Fischer-Schuch, Eckhard Thines, Florence Fontaine, Patricia Trotel-Aziz

Abstract read
In one paragraph

Article in Frontiers in plant science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Idir SaberUniversité de Reims Champagne-Ardenne, INRAE, RIBP UMR 1488, Reims, France.
Larissa Zeltner-HeckUniversité de Reims Champagne-Ardenne, INRAE, RIBP UMR 1488, Reims, France.
Laëtitia ParentUniversité de Reims Champagne-Ardenne, INRAE, RIBP UMR 1488, Reims, France.
Simon RemyUniversité de Reims Champagne Ardenne, Institut de Chimie Moléculaire de Reims UMR CNRS 7312, Reims, France.
Anthony Abou DibUniversité de Reims Champagne Ardenne, Institut de Chimie Moléculaire de Reims UMR CNRS 7312, Reims, France.
Jean-Hugues RenaultUniversité de Reims Champagne Ardenne, Institut de Chimie Moléculaire de Reims UMR CNRS 7312, Reims, France.
Jochen Fischer-SchuchInstitute for Biotechnology and Drug Research, Johannes Gutenberg-University, Mainz, Germany.
Eckhard ThinesInstitute for Biotechnology and Drug Research, Johannes Gutenberg-University, Mainz, Germany.
Florence FontaineUniversité de Reims Champagne-Ardenne, INRAE, RIBP UMR 1488, Reims, France.
Patricia Trotel-AzizUniversité de Reims Champagne-Ardenne, INRAE, RIBP UMR 1488, Reims, France.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Assessing the virulence of Methods: In this study, we employed a sterilized grapevine plantlet model artificially inoculated with distinct Np strains to evaluate the direct incidence of a living vine on Np metabolome, including phytotoxin production. Virulence is quantified based on the percentage of necrosis in infected plantlets and correlated with metabolomic profiles specific to the Np strains. Metabolites are analyzed in both culture medium and plantlet tissues by LC-MS, with an additional HPLC quantification of the main phytotoxins mellein (M) and terremutin (T). Results: Necroses range from 11.7% with NpB-UV9 to 33.5% with Np-Bt67 at 8 dpi, then from 34.2% with NpB-UV9 to 93.3% with Np-Bt67 at 14 dpi. Phytotoxin M is consistently detected in both medium and plant tissues and is produced at high levels by strain NpB-UV9. In contrast, T is mainly detected in the culture medium and is predominantly produced by strain Np-Bt67, which caused the most rapid and extensive necrosis in plantlets. Notably, production of both toxins is stimulated by living grapevine. Additional metabolites of both fungal and plant origin are also identified. Discussion: Collectively, these results demonstrate that living grapevine exacerbates the virulence activity of distinct Np strains, for which M and T appear as conserved virulence factors relevant for detection of Np infection in necrotic grapevine tissues.

Indexed as

Botryosphaeria diebackfungal pathogenmetabolomicsecondary metabolitesvirulence factorsVitis vinifera

Identifiers

PMID42620491
PMCPMC13485950

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.