Evidence map›Paper›PMID 42620475›Full record

ArticleResearch square2026

Breast Cancer Risk After Benign Breast Disease Among Racially Diverse Women: Systematic Review and Meta-Analysis.

Alzina Koric, Nusrat Preema, Akila Anandarajah, Shivani Patel, Angela Hardi, Graham A Colditz

Abstract readPreprint
In one paragraph

Article in Research square, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Alzina KoricWashington University in St. Louis.
Nusrat PreemaWashington University in St. Louis.
Akila AnandarajahVanderbilt University.
Shivani PatelSt. Joseph Medical Center.
Angela HardiWashington University in St. Louis.
Graham A ColditzWashington University in St. Louis.

Funding

Washington University Center for Cellular ImagingP30CA091842 · NCI · WASHINGTON UNIVERSITY · PI TIMOTHY J. EBERLEIN · 2001 to 2026
$128.0M
Postdoctoral Training in Cancer Prevention and ControlT32CA190194 · NCI · WASHINGTON UNIVERSITY · PI GRAHAM A. COLDITZ, AIMEE S JAMES · 2014 to 2026
$4.7M
NCI NIH HHS P30 CA091842NCI NIH HHS T32 CA190194
6 · The paper itself

Abstract

A meta-analysis of the existing literature was conducted to quantify breast cancer risk according to histologic subtype of benign breast disease (BBD) among women of diverse racial and ethnic backgrounds worldwide. PubMed (Medline), EMBASE (Emtree), and other relevant biomedical databases were searched through February 2026 to identify studies reporting the development of subsequent breast cancer in women diagnosed with either nonproliferative disease (NP), proliferative disease without atypia (PDWA), or atypical hyperplasia (AH). Seven studies met the eligibility criteria. Women of Asian ancestry with PDWA or AH had a substantially higher risk of breast cancer than those with NP. Among Black women, breast cancer risk associated with BBD subtypes was comparable to historically reported risks among White women, whereas associations among Hispanic women were less clear due to greater data limitations. The variable BBD-associated breast cancer risk across racial groups warrants confirmation and underscores the need for further investigation of the mechanisms underlying these differences.

Indexed as

Benign breast diseasebreast cancerethnicitymeta-analysisraceworldwide

Identifiers

PMID42620475
PMCPMC13484869

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.