Evidence map›Paper›PMID 42620323›Full record

ArticlemedRxiv : the preprint server for health sciences2026

Association between saturated fat intake and low-density lipoprotein cholesterol across the genetic spectrum: Results from the Women's Health Initiative.

Alexa Barad, Victor Ritter, Matthew Nudy, Linda Van Horn, Matthew A Allison, Cassandra N Spracklen, Longjian Liu, Su Yon Jung, JoAnn E Manson, Themistocles L Assimes and 2 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Alexa BaradDepartment of Medicine, Stanford Prevention Research Center, Stanford University School of Medicine, Stanford University, Stanford, CA, USA.ORCID 0000-0002-3940-362X
Victor RitterDepartment of Medicine, Stanford Prevention Research Center, Stanford University School of Medicine, Stanford University, Stanford, CA, USA.
Matthew NudyDepartment of Medicine and Public Health Sciences, Penn State College of Medicine, Hershey, PA, USA.
Linda Van HornDepartment of Preventive Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
Matthew A AllisonDepartment of Family Medicine, University of California San Diego, La Jolla, CA, USA.
Cassandra N SpracklenDepartment of Biostatistics and Epidemiology, University of Massachusetts Amherst, Amherst, MA, USA.ORCID 0000-0003-3590-7182
Longjian LiuDepartment of Epidemiology and Biostatistics, Dornsife School of Public Health, Drexel,University, Philadelphia, PA, USA.
Su Yon JungTranslational Sciences Section, School of Nursing, Department of Epidemiology, Fielding, School of Public Health, Jonsson Comprehensive Cancer Center, University of California, Los, Angeles, Los Angeles, CA, USA.
JoAnn E MansonDepartment of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Themistocles L AssimesDepartment of Medicine, Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford University, Stanford, CA, USA.ORCID 0000-0003-2349-0009
Marcia L StefanickDepartment of Medicine, Stanford Prevention Research Center, Stanford University School of Medicine, Stanford University, Stanford, CA, USA.
Shoa L ClarkeDepartment of Medicine, Stanford Prevention Research Center, Stanford University School of Medicine, Stanford University, Stanford, CA, USA.ORCID 0000-0002-6592-1172

Funding

WOMEN'S HEALTH INITIATIVE - CLINICAL COORDINATING CENTER: TASK AREA B - LONG LIFE STUDY VISIT 2 LIMITED HOME VISIT75N92021D00001 · NHLBI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI ANDERSON, GARNET L. · 2021 to 2025
$52.0M
WOMEN'S HEALTH INITIATIVE (WHI) REGIONAL CENTER (RC): TASK AREA A AND A275N92021D00002 · NHLBI · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI WACTAWSKI-WENDE, JEAN · 2021 to 2025
$6.9M
WOMEN'S HEALTH INITIATIVE (WHI) REGIONAL CENTER (RC) - TO EXERCISE OPTION PERIOD ONE (1) AND REVISE CONTRACT ARTICLES.75N92021D00004 · NHLBI · STANFORD UNIVERSITY · PI STEFANICK, MARCIA · 2021 to 2025
$6.5M
WOMEN'S HEALTH INITIATIVE (WHI) REGIONAL CENTER (RC) - TO EXERCISE OPTION PERIOD ONE (1) AND REVISE CONTRACT ARTICLES.75N92021D00003 · NHLBI · OHIO STATE UNIVERSITY · PI JACKSON, REBECCA · 2021 to 2025
$5.0M
WOMEN'S HEALTH INITIATIVE (WHI) REGIONAL CENTER (RC) - TO EXERCISE OPTION PERIOD ONE (1) AND REVISE CONTRACT ARTICLES.75N92021D00005 · NHLBI · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI VITOLINS, MARA · 2021 to 2025
$4.2M
NHLBI NIH HHS 75N92021D00001NHLBI NIH HHS 75N92021D00002WHI NIH HHS 75N92021D00003WHI NIH HHS 75N92021D00004WHI NIH HHS 75N92021D00005
6 · The paper itself

Abstract

Background: Elevated low-density lipoprotein cholesterol (LDL-C) is a causal risk factor for atherosclerotic cardiovascular disease (ASCVD). Guidelines recommend reducing saturated fat intake to lower LDL-C. However, the response to saturated fat in the diet is highly heterogeneous. Genetic factors may contribute to individual differences in response to saturated fat. Objectives: We aimed to examine whether genetic propensity for higher LDL-C modifies the association of saturated fat intake with LDL-C and incident ASCVD. Methods: We studied 20,940 genotyped postmenopausal women from the Women's Health Initiative. Exposures included saturated fat intake (percentage of total calories) derived from food frequency questionnaires and a genome-wide polygenic score for LDL-C (PGS Results: The median LDL-C at baseline for participants with PGS Conclusions: These findings suggest that the association between saturated fat intake and LDL-C and subsequent ASCVD risk may be stronger for individuals with a genetic propensity towards high LDL-C.

Indexed as

gene-diet interactionslow-density lipoprotein cholesterolpolygenic scoresaturated fat

Identifiers

PMID42620323
PMCPMC13484769

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.