Evidence map›Paper›PMID 42620316›Full record

ReviewJournal of pharmaceutical analysis2026

Exploring the potential of natural products in treating alopecia areata.

Baoli He, Yujia Weng, Peihua Luo, Zhifei Xu, Hao Yan, Bo Yang, Qiaojun He, Jiabin Lu, Xiaochun Yang

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of pharmaceutical analysis, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Baoli HeCenter for Drug Safety Evaluation and Research, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, 310058, China.
Yujia WengCenter for Drug Safety Evaluation and Research, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, 310058, China.
Peihua LuoCenter for Drug Safety Evaluation and Research, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, 310058, China.
Zhifei XuCenter for Drug Safety Evaluation and Research, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, 310058, China.
Hao YanCenter for Drug Safety Evaluation and Research, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, 310058, China.
Bo YangCenter for Drug Safety Evaluation and Research, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, 310058, China.
Qiaojun HeCenter for Drug Safety Evaluation and Research, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, 310058, China.
Jiabin LuCenter for Drug Safety Evaluation and Research, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, 310058, China.
Xiaochun YangCenter for Drug Safety Evaluation and Research, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, 310058, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Alopecia areata (AA) is an autoimmune disorder characterized by sudden hair loss, affecting millions worldwide. Conventional synthetic drug treatments are often limited by side effects, driving interest in natural alternatives. This review highlights terpenoids, flavonoids, and polyphenols as promising natural compounds that effectively promote hair regrowth in AA. These phytochemicals exert therapeutic effects primarily by activating pro-anagenic signaling pathways, notably the Wnt/β-catenin and phosphoinositide 3-kinase-protein kinase B (PI3K-Akt) pathways, while inhibiting catagen-associated pathways such as transforming growth factor-β (TGF-β), and modulating immune dysregulation through the suppression of Janus kinase-signal transducer and activator of transcription (JAK-STAT) signaling. This review has detailed the mechanisms through which these compounds support hair follicle regeneration, restore immune balance, and reduce inflammation. Collectively, the evidence highlights the significant therapeutic potential of natural products for AA, underscoring the need for further translational research.

Indexed as

Alopecia areataHair follicle immune privilegeNatural productsPhytochemicals

Identifiers

PMID42620316
PMCPMC13485652

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.