Evidence map›Paper›PMID 42620289›Full record

ArticlebioRxiv : the preprint server for biology2026

CRISPR-activation reveals key resistance genes and vulnerabilities of copy number variants in

Pétra L Vande Zande, Nicholas C Gervais, Erika Schell, Piper Zajac, Katura Metzner, Rebecca S Shapiro, Anna Selmecki

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Pétra L Vande ZandeDepartment of Microbiology and Immunology, University of Minnesota Medical School, Minneapolis, MN, USA.ORCID 0000-0002-4789-9899
Nicholas C GervaisDepartment of Molecular and Cellular Biology, University of Guelph, Guelph, Canada.ORCID 0000-0002-9971-0031
Erika SchellDepartment of Microbiology and Immunology, University of Minnesota Medical School, Minneapolis, MN, USA.
Piper ZajacDepartment of Microbiology and Immunology, University of Minnesota Medical School, Minneapolis, MN, USA.ORCID 0009-0006-6183-7324
Katura MetznerDepartment of Microbiology and Immunology, University of Minnesota Medical School, Minneapolis, MN, USA.ORCID 0000-0003-1207-6216
Rebecca S ShapiroDepartment of Molecular and Cellular Biology, University of Guelph, Guelph, Canada.ORCID 0000-0002-7119-8865
Anna SelmeckiDepartment of Microbiology and Immunology, University of Minnesota Medical School, Minneapolis, MN, USA.ORCID 0000-0003-3298-2400

Funding

Aneuploidy and Acquired Antifungal Drug Resistance in Candida speciesR01AI143689 · NIAID · UNIVERSITY OF MINNESOTA · PI Anna M. Selmecki · 2020 to 2026
$3.2M
Impacts of copy number variation on gene regulatory networks and fitness in CandidaK99GM160701 · NIGMS · UNIVERSITY OF MINNESOTA · PI Petra Vande Zande · 2025 to 2026
$250k
NIAID NIH HHS R01 AI143689NIGMS NIH HHS K99 GM160701
6 · The paper itself

Abstract

Changes in gene copy number are an extremely important source of variation and are frequently observed during the acquisition of drug resistance. The opportunistic human fungal pathogen

Indexed as

adaptationcopy number variationCRISPR-activationdrug resistanceoverexpression

Identifiers

PMID42620289
PMCPMC13484733

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.