ArticleResearch square2026
Estradiol and memory circuitry in the postmenopause: Modification by APOE4.
Rahel A Schroeder, Rebecca C Thurston, Minjie Wu, Howard J Aizenstein, Thomas K Karikari, M Ilyas Kamboh, Ann D Cohen, Pauline M Maki
Abstract readPreprint
In one paragraphArticle in Research square, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
8 authors.
Rahel A SchroederDepartment of Psychology, University of Illinois Chicago, Chicago, IL, USA.
Rebecca C ThurstonDepartments of Psychiatry, Psychology, Epidemiology, and Clinical and Translational Science, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.ORCID 0000-0001-6580-1202 Minjie WuDepartment of Psychiatry, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.
Howard J AizensteinDepartments of Psychiatry, Psychology, Epidemiology, and Clinical and Translational Science, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Thomas K KarikariUniversity of Pittsburgh Alzheimer's Disease Research Center (ADRC), Pittsburgh, PA, USA.ORCID 0000-0003-1422-4358 M Ilyas KambohUniversity of Pittsburgh Alzheimer's Disease Research Center (ADRC), Pittsburgh, PA, USA.ORCID 0000-0002-3453-1438 Ann D CohenUniversity of Pittsburgh Alzheimer's Disease Research Center (ADRC), Pittsburgh, PA, USA.
Pauline M MakiDepartments of Psychiatry, Psychology, and Obstetrics & Gynecology, University of Illinois Chicago, Chicago, IL, USA.
Funding
University of Pittsburgh Clinical and Translational Science InstituteUL1TR000005 · NCATS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI REIS, STEVEN E · 2012 to 2015
$50.8MMenopausal Vasomotor Symptoms and Brain Aging in WomenRF1AG053504 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI MAKI, PAULINE M, THURSTON, REBECCA C · 2016 to 2019
$4.1MMenopausal Vasomotor Symptoms and Brain Aging in WomenR01AG053504 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI MAKI, PAULINE M, THURSTON, REBECCA C · 2021 to 2025
$3.8MAPI 4000 QTRAPS10RR023461 · NCRR · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI POLOYAC, SAMUEL M · 2007 to 2007
$487kNCATS NIH HHS UL1 TR000005NCRR NIH HHS S10 RR023461NIA NIH HHS R01 AG053504NIA NIH HHS RF1 AG053504
6 · The paper itselfAbstract
Background: Menopause-related declines in endogenous estrogen have been implicated in the higher risk of Alzheimer's disease (AD) in female Methods: 172 postmenopausal women (mean age=59.3±3.9 years, 83% white, 23.33% Results: Conclusion: In women
Indexed as
Alzheimer’s diseaseAPOE4estradiolfMRImemorymenopause
Identifiers
PMID42620244
PMCPMC13484806
What OpenQuestion holds
Textmetadata
LicenceCC BY
Read underepoch 390