Evidence map›Paper›PMID 42620231›Full record

ArticleResearch square2026

Mesothelial Plasticity Specifies Divergent Pleural Immune Circuits that Instruct Lung Regeneration versus Degeneration.

Le Xu, Kevin H Chen, Barsha Dash, Bingpeng Yao, Rongbo Li, Xingan Wang, Zihe Zhou, Vincent Yu, Rebecca Salamon, Pushpinder S Bawa and 6 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in Research square, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Le XuDepartment of Pediatrics, School of Medicine, University of California San Diego, La Jolla, CA 92093, USA.
Kevin H ChenCenter for Regenerative Medicine of Boston University and Boston Medical Center, Boston, MA; The Pulmonary Center and Department of Medicine, Boston University School of Medicine, Boston, MA, 02118, USA.
Barsha DashDepartment of Pediatrics, School of Medicine, University of California San Diego, La Jolla, CA 92093, USA.
Bingpeng YaoDepartment of Pediatrics, School of Medicine, University of California San Diego, La Jolla, CA 92093, USA.
Rongbo LiDepartment of Pediatrics, School of Medicine, University of California San Diego, La Jolla, CA 92093, USA.ORCID 0000-0001-9112-9712
Xingan WangDivision of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, University of Pittsburgh, Pittsburgh, PA, 15260, USA.
Zihe ZhouDivision of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, University of Pittsburgh, Pittsburgh, PA, 15260, USA.
Vincent YuDepartment of Pediatrics, School of Medicine, University of California San Diego, La Jolla, CA 92093, USA.
Rebecca SalamonDepartment of Pediatrics, School of Medicine, University of California San Diego, La Jolla, CA 92093, USA.
Pushpinder S BawaCenter for Regenerative Medicine of Boston University and Boston Medical Center, Boston, MA; The Pulmonary Center and Department of Medicine, Boston University School of Medicine, Boston, MA, 02118, USA.
Minzhe GuoDivision of Pulmonary Biology, Perinatal Institute, Cincinnati Children's Hospital Medical Center (CCHMC), Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA.ORCID 0000-0002-5502-9172
Zea BorokDivision of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, University of California, San Diego, La Jolla, CA 92093, USA.ORCID 0000-0001-8673-8177
Darrell N KottonCenter for Regenerative Medicine of Boston University and Boston Medical Center, Boston, MA; The Pulmonary Center and Department of Medicine, Boston University School of Medicine, Boston, MA, 02118, USA.ORCID 0000-0002-9604-8476
Oliver EickelbergDivision of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, University of Pittsburgh, Pittsburgh, PA, 15260, USA.
Marta BuenoDivision of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, University of Pittsburgh, Pittsburgh, PA, 15260, USA.
Xin SunDepartment of Pediatrics, School of Medicine, University of California San Diego, La Jolla, CA 92093, USA.ORCID 0000-0001-8387-4966

Funding

U of Calif, San Diego Neuroscience Microscopy ImagingP30NS047101 · NINDS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI GLEESON, JOSEPH G, ZHENG, BINHAI · 2003 to 2022
$9.0M
Mechanosensor Function in the Control of Gas Exchange Surface Size and CompositionR01HL169853 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Xin Sun · 2023 to 2026
$2.2M
MYRF as an Entry Point to Study Mesothelium Function in Lung Development and Injury RepairR01HL172027 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Xin Sun · 2024 to 2026
$1.7M
Illumina NovaSeq 6000 Sequencing SystemS10OD026929 · OD · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI JEPSEN, KRISTEN LYNN · 2019 to 2019
$600k
Frontiers at the edge: Subpleural fibroblasts orchestrate pulmonary fibrosis progressionR00HL171830 · NHLBI · CINCINNATI CHILDRENS HOSP MED CTR · PI Le Xu · 2026 to 2026
$249k
NHLBI NIH HHS R00 HL171830NHLBI NIH HHS R01 HL169853NHLBI NIH HHS R01 HL172027NIH HHS S10 OD026929NINDS NIH HHS P30 NS047101
6 · The paper itself

Abstract

Following injury, predisposition towards regenerative repair and away from degenerative remodeling is central to organismal health, yet the upstream determinants that instruct this fate choice remain poorly understood. Here, we identify mesothelial cell plasticity as a central determinant between regeneration and degeneration by comparing mouse models of pneumonectomy (PNX) versus chronic lung allograft dysfunction (CLAD). While mesothelial cells expand in both settings, following PNX, these cells undergo differentiation through multiple transitional states, culminating in an inflammatory population that orchestrates monocyte recruitment and subsequent tissue regeneration. In contrast, in CLAD, mesothelial cells enrich in an extracellular matrix-enriched state that lacks pro-regenerative signaling capacity. Using single cell epigenomic profiling and in vivo genetics, we define a mesothelium-specific TWIST1-CCL2 axis that governs mesothelium plasticity and signaling, monocyte recruitment and lung regrowth. Together, these findings demonstrate that context-dependent reprogramming of a pleural population, known to protect organs, can be leveraged to drive regeneration.

Identifiers

PMID42620231
PMCPMC13484444

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.