Evidence map›Paper›PMID 42620228›Full record

ArticleResearch square2026

Hyperpolarized

Tamara Vasilkovska, Lydia M Le Page, Caroline Guglielmetti, Marina Radoul, Huihui Li, Xiao Ji, Jeremy W Gordon, Ken Nakamura, Myriam M Chaumeil

Abstract readPreprint
In one paragraph

Article in Research square, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Tamara VasilkovskaUniversity of California, San Francisco.
Lydia M Le PageUniversity of California, San Francisco.
Caroline GuglielmettiUniversity of California, San Francisco.
Marina RadoulUniversity of California, San Francisco.
Huihui LiGladstone Institutes.
Xiao JiUniversity of California, San Francisco.
Jeremy W GordonUniversity of California, San Francisco.
Ken NakamuraGladstone Institutes.
Myriam M ChaumeilUniversity of California, San Francisco.

Funding

Defining Strategies to Target Energy Failure in Metabolically Vulnerable Human CellsR01AG065428 · NIA · J. DAVID GLADSTONE INSTITUTES · PI NAKAMURA, KEN · 2020 to 2024
$3.7M
Understand and probing disrupted glucose metabolism in Alzheimer's diseaseRF1AG064170 · NIA · J. DAVID GLADSTONE INSTITUTES · PI CHAUMEIL, MYRIAM MARIANNE, NAKAMURA, KEN · 2019 to 2019
$3.6M
MR Metabolic Imaging of Multiple SclerosisR01NS102156 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Jeremy William Gordon, Ari J Green · 2017 to 2026
$3.4M
EXTRAMULAR RESEARCH FACILITIES CONSTRUCTIONC06RR018928 · NCRR · J. DAVID GLADSTONE INSTITUTES · PI MAHLEY, ROBERT W. · 2003 to 2003
$2.1M
Imaging innate and adaptive immune response in MS using using [18F]F-AraG PET and hyperpolarized 13C MRSIR21AI153749 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI CHAUMEIL, MYRIAM MARIANNE, GUGLIELMETTI, CAROLINE · 2020 to 2021
$444k
NCRR NIH HHS C06 RR018928NIAID NIH HHS R21 AI153749NIA NIH HHS R01 AG065428NIA NIH HHS RF1 AG064170NINDS NIH HHS R01 NS102156
6 · The paper itself

Abstract

Impaired brain energy metabolism is an early feature of Alzheimer's disease (AD), but the standard metabolic imaging tool, [

Indexed as

Alzheimer’s diseaseamyloid betabiomarkerbrain metabolismhyperpolarized 13C MRSImetabolomics

Identifiers

PMID42620228
PMCPMC13484443

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.