ArticleResearch square2026
Effect of tango versus exercise on chemotherapy-induced neuropathy after breast cancer treatment: a Phase II randomized controlled trial.
Article in Research square, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05114005 (Dance-Based Avenues to Advance Nonpharmacologic Treatment of Chemotherapy Effects), which is not on this map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Dance-Based Avenues to Advance Nonpharmacologic Treatment of Chemotherapy Effects (DAANCE)
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20 authors.
Funding
Abstract
backgroundUp to 80% of individuals with breast cancer treated with chemotherapy develop chemotherapy-induced neuropathy (CIN), a dose-limiting neurotoxic response that degrades postural control, sensory function, and quality of life. To evaluate nonpharmacologic solutions for neuromotor dysfunction among individuals with breast cancer and CIN, we performed a randomized controlled trial of two physical activity protocols: Tango Dance (Tango) and Home Exercise (control).
methodsWe enrolled 51 survivors (mean (SD) = 61.2(9.74) years; female: n=50; male: n=1) with breast cancer, CIN, and postural control deficits. We randomized participants 1:1 into Tango (n=25) or Home Exercise (n=26) intervention arms and conducted both interventions for 8 weeks, 2x per week, for up to 60 minutes per class. Postural control function was measured with eyes closed (QEC) and center of pressure (COP) variables calculated included postural sway amplitude (RMSr (primary), RMSx), sway area (COPa). Additionally, we evaluated patient-reported symptoms, clinical function, participation barriers, and adverse events.
resultsFunction, neuropathy symptoms, and fatigue improved with both Tango and Home Exercise intervention. Tango alone evidenced retention of postural control improvements after intervention end (RMSr, p=0.0455; RMSx, p=0.0165; COPa, p=0.0183). Tango alone improved Common Terminology Criteria for Adverse Events patient-reported (PRO-CTCAE) symptoms at 4 (p=0.0402) and 6 (p=0.0110) weeks of training.
conclusionBoth Tango and Home Exercise improve CIN-related deficits. Tango was superior to Home Exercise in two ways: alleviating symptoms at intervention midpoint and supporting retention of neuromotor gains. Further study is required to identify mechanisms driving these effects.
trial registrationNCT05114005 (registered 08/15/2021, completed 04/15/2024).
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