Evidence map›Paper›PMID 42620181›Full record

ArticlebioRxiv : the preprint server for biology2026

A conserved vesicular circuit enables metabolic adaptation and maintains systemic heme homeostasis.

Sohini Dutt, Simon Beardsley, Xiaojing Yuan, Ran Yu, Audrey Belot, Blake Carrington, Kevin Bishop, Sandeepan Ghosh, Jiayu Li, Xuedi Zhang and 12 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors.

Sohini DuttCenter for Blood Oxygen Transport and Hemostasis, Department of Pediatrics, School of Medicine, University of Maryland, Baltimore, Maryland, USA.
Simon BeardsleyDepartment of Animal and Avian Sciences, University of Maryland, College Park, Maryland, USA.
Xiaojing YuanCenter for Blood Oxygen Transport and Hemostasis, Department of Pediatrics, School of Medicine, University of Maryland, Baltimore, Maryland, USA.
Ran YuCenter for Blood Oxygen Transport and Hemostasis, Department of Pediatrics, School of Medicine, University of Maryland, Baltimore, Maryland, USA.
Audrey BelotCenter for Blood Oxygen Transport and Hemostasis, Department of Pediatrics, School of Medicine, University of Maryland, Baltimore, Maryland, USA.
Blake CarringtonZebrafish Core, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, USA.
Kevin BishopZebrafish Core, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, USA.
Sandeepan GhoshCenter for Blood Oxygen Transport and Hemostasis, Department of Pediatrics, School of Medicine, University of Maryland, Baltimore, Maryland, USA.
Jiayu LiMOE Key Laboratory of Biosystems Homeostasis and Protection, College of Life Sciences, Zhejiang University, Hangzhou, China.
Xuedi ZhangCenter for Blood Oxygen Transport and Hemostasis, Department of Pediatrics, School of Medicine, University of Maryland, Baltimore, Maryland, USA.
Jean-Martin HarderFaculty of Chemistry and Earth Sciences, Institute of Organic Chemistry and Macromolecular Chemistry, Friedrich Schiller University Jena, Jena, Germany.
Rutwick Surya UlhasFaculty of Chemistry and Earth Sciences, Institute of Organic Chemistry and Macromolecular Chemistry, Friedrich Schiller University Jena, Jena, Germany.
Shilpa Dilip KumarDepartment of Pharmacology and Physiology, School of Medicine, University of Maryland, Baltimore, Maryland, USA.
Vijaya PandeyDepartment of Biological Chemistry, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, USA.
Raman SoodZebrafish Core, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, USA.
Harold SmithLaboratory of Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, USA.
Michael KrauseLaboratory of Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, USA.
James A WohlschlegelDepartment of Biological Chemistry, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, USA.
Ute A HellmichFaculty of Chemistry and Earth Sciences, Institute of Organic Chemistry and Macromolecular Chemistry, Friedrich Schiller University Jena, Jena, Germany.
Caiyong ChenMOE Key Laboratory of Biosystems Homeostasis and Protection, College of Life Sciences, Zhejiang University, Hangzhou, China.
Paul LiuOncogenesis and Development Section, Translational and Functional Genomics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, USA.
Iqbal HamzaCenter for Blood Oxygen Transport and Hemostasis, Department of Pediatrics, School of Medicine, University of Maryland, Baltimore, Maryland, USA.ORCID 0000-0003-0045-0610

Funding

The Biological Role of Heme in NutritionR01DK074797 · NIDDK · UNIV OF MARYLAND, COLLEGE PARK · PI Iqbal Hamza · 2006 to 2026
$5.4M
Heme trafficking and recycling in iron metabolismR01DK125740 · NIDDK · UNIV OF MARYLAND, COLLEGE PARK · PI HAMZA, IQBAL · 2020 to 2023
$1.9M
Zeiss LSM 880 Airyscan Fast Laser Scanning ConfocalS10OD025223 · OD · UNIV OF MARYLAND, COLLEGE PARK · PI BEAVEN, AMY · 2019 to 2019
$557k
NIDDK NIH HHS R01 DK074797NIDDK NIH HHS R01 DK125740NIH HHS S10 OD025223
6 · The paper itself

Abstract

Metabolic homeostasis depends on adaptive control of intracellular metabolite flux, yet how such control is reconfigured when canonical transport pathways fail is unknown. Here we define a conserved vesicular circuit that preserves systemic heme balance by rerouting intracellular heme flux. We show that loss of the intestinal heme exporter MRP-5 in

Identifiers

PMID42620181
PMCPMC13484576

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.