Evidence map›Paper›PMID 42620166›Full record

ArticleResearch square2026

Machine Learning-Accelerated Analysis of

Abhishri Medewar, Andrew DuPlissis, Adam Laing, Amber Shen, Evan Hegarty, Sebastian Gomez, Gina Carrion, Julia Brown, Sudip Mondal, Adela Ben-Yakar

Abstract readPreprint
In one paragraph

Article in Research square, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Abhishri MedewarvivoVerse, LLC, Austin, TX 78731, USA.
Andrew DuPlissisvivoVerse, LLC, Austin, TX 78731, USA.
Adam LaingvivoVerse, LLC, Austin, TX 78731, USA.
Amber ShenvivoVerse, LLC, Austin, TX 78731, USA.
Evan HegartyvivoVerse, LLC, Austin, TX 78731, USA.
Sebastian GomezvivoVerse, LLC, Austin, TX 78731, USA.
Gina CarrionvivoVerse, LLC, Austin, TX 78731, USA.
Julia BrownvivoVerse, LLC, Austin, TX 78731, USA.
Sudip MondalvivoVerse, LLC, Austin, TX 78731, USA.
Adela Ben-YakarvivoVerse, LLC, Austin, TX 78731, USA.

Funding

A Multiwell Plate Format Microfluidic Immobilization Chip for High-Content Imaging of Whole Animals for in vivoNeurotoxicology TestingR44MH118841 · NIMH · VIVOVERSE, LLC · PI HEGARTY, EVAN · 2020 to 2022
$2.2M
The Next-Generation Developmental and Reproductive Toxicology (DART) Assay using High-Content Analysis of Genetically Diverse C. elegans PopulationsR44ES033579 · NIEHS · VIVOVERSE, LLC · PI HEGARTY, EVAN · 2023 to 2024
$1.8M
High-content study to analyze the nutritional value of natural products for healthy agingR43AT013187 · NCCIH · VIVOVERSE, LLC · PI MONDAL, SUDIP · 2025 to 2025
$307k
High-Content in vivo DNT Test Batteries using Cell-Specific Characterization of the Neurodevelopment and Synaptogenesis in C. elegans as NAMsR43ES036387 · NIEHS · VIVOVERSE, LLC · PI MONDAL, SUDIP · 2024 to 2024
$287k
A multiwell plate format microfluidic immobilization chip for high-content imaging of whole animalsR43MH118841 · NIMH · VIVOVERSE, LLC · PI HEGARTY, EVAN · 2018 to 2019
$273k
The Next-Generation Developmental and Reproductive Toxicology (DART) Assay using High-Content Analysis of Genetically Diverse C. elegans PopulationsR43ES033579 · NIEHS · VIVOVERSE, LLC · PI HEGARTY, EVAN · 2021 to 2021
$254k
NCCIH NIH HHS R43 AT013187NIEHS NIH HHS R43 ES033579NIEHS NIH HHS R43 ES036387NIEHS NIH HHS R44 ES033579NIMH NIH HHS R43 MH118841NIMH NIH HHS R44 MH118841
6 · The paper itself

Abstract

Predictive new approach methodologies (NAMs) for developmental and reproductive toxicity (DART) assessment are increasingly needed as reliance on conventional mammalian studies decreases and chemical safety evaluation demands continue to expand. Whole-organism NAMs, including

Indexed as

acceptance criteriaartificial intelligenceautomated analysisC. elegansdevelopmental and reproductive toxicity (DART)high-resolution imagingin utero embryo phenotypeMachine learningmicrofluidic technologyrepeatable assays

Identifiers

PMID42620166
PMCPMC13484873

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.